Current understanding of the molecular and cellular pathology of diabetic retinopathy

DA Antonetti, PS Silva, AW Stitt - Nature Reviews Endocrinology, 2021 - nature.com
Diabetes mellitus has profound effects on multiple organ systems; however, the loss of
vision caused by diabetic retinopathy might be one of the most impactful in a patient's life …

New insights into antiangiogenic therapy resistance in cancer: Mechanisms and therapeutic aspects

M Huang, Y Lin, C Wang, L Deng, M Chen… - Drug resistance …, 2022 - Elsevier
Angiogenesis is a hallmark of cancer and is required for tumor growth and progression.
Antiangiogenic therapy has been revolutionarily developing and was approved for the …

Mechanisms of new blood-vessel formation and proliferative heterogeneity of endothelial cells

H Naito, T Iba, N Takakura - International immunology, 2020 - academic.oup.com
The vast blood-vessel network of the circulatory system is crucial for maintaining bodily
homeostasis, delivering essential molecules and blood cells, and removing waste products …

Tumor endothelial cells accelerate tumor metastasis

N Maishi, K Hida - Cancer science, 2017 - Wiley Online Library
Tumor metastasis is the main cause of cancer‐related death. Understanding the molecular
mechanisms underlying tumor metastasis is crucial to control this fatal disease. Several …

Tumor endothelial cells (TECs) as potential immune directors of the tumor microenvironment–new findings and future perspectives

L Nagl, L Horvath, A Pircher, D Wolf - Frontiers in cell and …, 2020 - frontiersin.org
The tumor microenvironment (TME) plays a central role in cancer development and
progression. It represents a complex network of cancer cell (sub-) clones and a variety of …

Contribution of tumor endothelial cells in cancer progression

K Hida, N Maishi, DA Annan, Y Hida - International journal of molecular …, 2018 - mdpi.com
Tumor progression depends on the process of angiogenesis, which is the formation of new
blood vessels. These newly formed blood vessels supply oxygen and nutrients to the tumor …

The role of tumor-stroma interactions in drug resistance within tumor microenvironment

Y Ni, X Zhou, J Yang, H Shi, H Li, X Zhao… - Frontiers in cell and …, 2021 - frontiersin.org
Cancer cells resistance to various therapies remains to be a key challenge nowadays. For a
long time, scientists focused on tumor cells themselves for the mechanisms of acquired drug …

The role of non‐coding RNAs in drug resistance of oral squamous cell carcinoma and therapeutic potential

X Meng, QY Lou, WY Yang, YR Wang… - Cancer …, 2021 - Wiley Online Library
Oral squamous cell carcinoma (OSCC), the eighth most prevalent cancer in the world, arises
from the interaction of multiple factors including tobacco, alcohol consumption, and betel …

Monotherapy and combination therapy using anti‐angiogenic nanoagents to fight cancer

P Liang, B Ballou, X Lv, W Si, MP Bruchez… - Advanced …, 2021 - Wiley Online Library
Anti‐angiogenic therapy, targeting vascular endothelial cells (ECs) to prevent tumor growth,
has been attracting increasing attention in recent years, beginning with bevacizumab …

CD157 marks tissue-resident endothelial stem cells with homeostatic and regenerative properties

T Wakabayashi, H Naito, J Suehiro, Y Lin, H Kawaji… - Cell stem cell, 2018 - cell.com
The generation of new blood vessels via angiogenesis is critical for meeting tissue oxygen
demands. A role for adult stem cells in this process remains unclear. Here, we identified …