More than a decade after a Nobel Prize was awarded for the discovery of the ubiquitin–
proteasome system and clinical approval of proteasome and ubiquitin E3 ligase inhibitors …

Chromatin remodeling is an essential cellular process for organizing chromatin structure into
either open or close configuration at specific chromatin locations by orchestrating and …

Tumors have evolved in various mechanisms to evade the immune system, hindering the
antitumor immune response and facilitating tumor progression. Immunotherapy has become …

A growing amount of evidence suggests that ubiquitination and deubiquitination of
programmed death 1 (PD-1)/programmed death-ligand 1 (PD-L1) play crucial roles in the …

The ubiquitin/proteasome system is a primary conduit for selective intracellular protein
degradation. Since its discovery over 30 years ago, this highly regulated system continues to …

Low‐grade serous ovarian carcinoma (LGSOC) is associated with a poor response to
existing chemotherapy, highlighting the need to perform comprehensive genomic analysis …

Post-translational modifications such as ubiquitination play important regulatory roles in
several biological processes in eukaryotes. This process could be reversed by …

Since the discovery of the ubiquitin proteasome system (UPS), the roles of ubiquitinating
and deubiquitinating enzymes (DUBs) have been widely elucidated. The ubiquitination of …

Triple-negative breast cancer (TNBC) is a breast cancer subtype that lacks targeted
treatment options. The activation of the Notch developmental signaling pathway, which is a …

Alterations in protein ubiquitination and hypoxia-inducible factor (HIF) signaling both
contribute to tumorigenesis and tumor progression. Ubiquitination is a dynamic process that …