The clinical correlations linking diabetes mellitus with accelerated atherosclerosis,
cardiomyopathy, and increased post-myocardial infarction fatality rates are increasingly …

Cardiac remodelling is classified as physiological (in response to growth, exercise and
pregnancy) or pathological (in response to inflammation, ischaemia, ischaemia/reperfusion …

Exercise induces physiological cardiac growth and protects the heart against pathological
remodeling. Recent work suggests exercise also enhances the heart's capacity for repair …

Cardiac remodeling involves molecular, cellular, and in-terstitial changes that manifest
clinically as changes in size, shape, and function of the heart after injury or stress …

Rationale: Ca2+ homeostasis—a critical determinant of cardiac contractile function—is
critically regulated by SERCA2a (sarcoplasmic reticulum Ca2+-ATPase 2a). Our previous …

Background—A variety of studies carried out using either human subjects or laboratory
animals suggest that vitamin D and its analogues possess important beneficial activity in the …

Transverse aortic constriction (TAC) in the mouse is a commonly used experimental model
for pressure overload-induced cardiac hypertrophy and heart failure. 1 TAC initially leads to …

Diabetic nephropathy (DN) is a serious kidney-related complication of both type 1 and type 2
diabetes mellitus (T1DM, T2DM) and the second major cause of end-stage kidney disease …

MicroRNAs (miRs) are a class of single-stranded, non-coding RNAs of about 22 nucleotides
in length,. Increasing evidence implicates miRs in myocardial disease processes,,,,,,,,. Here …

Background: Exercise promotes metabolic remodeling in the heart, which is associated with
physiological cardiac growth; however, it is not known whether or how physical activity …