While the morphology and function of cells of the exocrine and endocrine pancreas have
been studied over several centuries, one important cell type in the gland, the pancreatic …

Highlights•Redox-related transcription factor upregulation characterizes inflammation-
related cancer.•NADPH oxidase-dependent ROS are associated with inflammation and …

Pancreatic stellate cells (PSCs) were identified in the early 1980s, but received much
attention after 1998 when the methods to isolate and culture them from murine and human …

Chronic liver injury, resulted from different etiologies (eg, virus infection, alcohol abuse,
nonalcoholic steatohepatitis (NASH) and cholestasis) can lead to liver fibrosis characterized …

Significance: Hepatic fibrosis is the common pathophysiologic process resulting from
chronic liver injury, characterized by the accumulation of an excessive extracellular matrix …

Pancreatic ductal adenocarcinoma (PDAC) is the most common form of pancreatic cancer
and is characterized by remarkable desmoplasia. The desmoplasia is composed of …

Reactive oxygen and reactive nitrogen species (ROS/RNS) have been implicated in the
pathogenesis of acute and chronic pancreatitis. Clinical and basic science studies have …

The members of the NOX/DUOX family of NADPH oxidases mediate such physiologic
functions as host defense, cell signaling, and thyroid hormone biosynthesis through the …

Significance: Prominent fibrosis is a major histological feature of chronic pancreatitis, a
progressive necroinflammatory condition of the pancreas, most commonly associated with …

Reactive oxygen species (ROS) have been implicated in many intra-and intercellular
processes. High levels of ROS are generated as part of the innate immunity in the …