With the development of trauma systems, improved resuscitation, and organ system support,
survival after severe injury is common, but is often complicated by nosocomial infection and …

Objectives: To familiarize clinicians with advances in computational disease modeling
applied to trauma and sepsis. Data Sources: PubMed search and review of relevant medical …

Background The appropriateness of vigorous fluid resuscitation to normal blood pressure
following hemorrhage in uncontrolled bleeding has recently been questioned due to the …

Our recent study showed that estrogen receptor (ER) β plays a major role in mediating the
salutary effects of 17β-estradiol (E2) on cardiac function following trauma–hemorrhage (T …

Objective DNA microarrays allow genome-wide assessment of changes in relative
messenger RNA abundance and thus can be used to monitor changes in gene expression …

Keloid scars after skin trauma are a significant clinical problem, especially in black
populations, in which the incidence of keloids has been estimated at 4–16%. Keloids are …

Flutamide, an androgen receptor antagonist, is thought to improve cardiovascular function
by blocking the androgen receptor after trauma-hemorrhage (TH). Although 17β-estradiol …

ABSTRACT PGC‐1α (peroxisome proliferator‐acti‐vated receptor [PPARγ] coactivator‐1α)
activates PPARα and mitochondrial transcription factor A (Tfam), which regulate proteins …

Trauma and hemorrhagic shock (HS) elicit severe physiological disturbances that
predispose the victims to subsequent organ dysfunction and death. The general lack of …

Context: Necrotizing fasciitis is an aggressive infection affecting the skin and soft tissue. It
has a very high acute mortality. The long-term survival and cause of death of patients who …