This review explores the historical and current state of our knowledge about urodele limb
regeneration. Topics discussed are (1) blastema formation by the proteolytic histolysis of …

Regeneration of missing body parts is an incredible ability which is present in a wide
number of species. However, this regenerative capability varies among different organisms …

Regeneration of complex multi-tissue structures, such as limbs, requires the coordinated
effort of multiple cell types. In axolotl limb regeneration, the wound epidermis and blastema …

Lizards cannot naturally regenerate limbs but are the closest known relatives of mammals
capable of epimorphic tail regrowth. However, the mechanisms regulating lizard blastema …

Connective tissues—skeleton, dermis, pericytes, fascia—are a key cell source for
regenerating the patterned skeleton during axolotl appendage regeneration. This complexity …

Regeneration and tissue turnover require new cell production and positional information.
Planarians are flatworms capable of regenerating all body parts using a population of stem …

Throughout the animal kingdom regenerative ability varies greatly from species to species,
and even tissue to tissue within the same organism. The sheer diversity of structures and …

Some organisms, such as the Mexican axolotl, have the capacity to regenerate complicated
biological structures throughout their lives. Which molecular pathways are sufficient to …

How salamanders accomplish progenitor cell proliferation while faithfully maintaining
genomic integrity and regenerative potential remains elusive. Here we found an innate DNA …

While the axolotl's ability to completely regenerate amputated limbs is well known and
studied, the mechanism of axolotl bone fracture healing remains poorly understood. One …