The neurotransmitter dopamine is a key factor in central nervous system (CNS) function,
regulating many processes including reward, movement, and cognition. Dopamine also …

Background: Among the many cannabinoids in the cannabis plant, cannabidiol (CBD) is a
compound that does not produce the typical subjective effects of marijuana. Objectives: The …

Depression is the most prevalent and among the most debilitating of psychiatric disorders.
The precise neurobiology of this illness is unknown. Several lines of evidence suggest that …

Evidence from clinical, preclinical, and post-mortem studies supports the
inflammatory/immune hypothesis of schizophrenia pathogenesis. Less evident is the link …

Despite a lack of recent progress in the treatment of schizophrenia, our understanding of its
genetic and environmental causes has considerably improved, and their relationship to …

BackgroundAccumulating evidence shows that a propensity towards a pro-inflammatory
status in the brain plays an important role in schizophrenia. Anti-inflammatory drugs might …

Microglia, the tissue-resident macrophages of the central nervous system (CNS), have
characterized roles in combating infection, clearing cellular debris, and maintaining tissue …

Maternal immune activation (MIA) during pregnancy has been linked to an increased risk of
developing psychiatric pathologies in later life. This link may be bridged by a defective …

Schizophrenia disorder remains an unsolved puzzle. However, the integration of recent
findings from genetics, molecular biology, neuroimaging, animal models and translational …

Background and purpose Minocycline is a broad‐spectrum antibiotic, effective as a chronic
treatment for recurrent bacterial infections. Beyond its antibiotic action, minocycline also has …