Rheumatoid arthritis (RA) is a chronic, systemic autoimmune disease associated with
synovial tissue proliferation, pannus formation, cartilage destruction, and systemic …

Rheumatoid arthritis is a heterogeneous disease, which can be, based on data combining
genetic risk factors and autoantibodies, sub-classified into ACPA-positive and-negative RA …

Rheumatoid arthritis (RA) is a systemic auto-immune disease principally effecting synovial
joints. RA is characterized by immune cell infiltration in the joint. The presence of …

Autoimmune diseases (AIDs) are the consequence of a breach in immune tolerance,
leading to the inability to sufficiently differentiate between self and non-self. Immune …

Individuals at high risk of developing seropositive rheumatoid arthritis (RA) can be identified
for translational research and disease prevention studies through the presence of highly …

Following fifteen years of research, neutrophil extracellular traps (NETs) are widely reported
in a large range of inflammatory infectious and non-infectious diseases. Cumulating …

Rheumatoid arthritis (RA) is an autoimmune disease characterized by joint inflammation.
The presence of autoantibodies in the sera of RA patients has provided many clues to the …

Although elevated levels of anti-citrullinated protein antibodies (ACPAs) are a hallmark of
rheumatoid arthritis (RA), the in vivo functions of these antibodies remain unclear. Here, we …

A key unanswered question in the pathophysiology of rheumatoid arthritis (RA) is how
systemic autoimmunity progresses to joint-specific inflammation. In patients with seropositive …

In this Review we focus on the initiation of autoantibody production and autoantibody
pathogenicity, with a special emphasis on the targeted antigens. Release of intracellular …