Signal-transduction pathways that regulate smooth muscle function I. Signal transduction in phasic (esophageal) and tonic (gastroesophageal sphincter) smooth …

KM Harnett, W Cao, P Biancani - American Journal of …, 2005 - journals.physiology.org
Contraction of esophageal (Eso) and lower esophageal sphincter (LES) circular muscle
depends on distinct signal-transduction pathways. ACh-induced contraction of Eso muscle is …

Gastroesophageal reflux disease–associated esophagitis induces endogenous cytokine production leading to motor abnormalities

F Rieder, L Cheng, KM Harnett, A Chak, GS Cooper… - Gastroenterology, 2007 - Elsevier
Background & Aims: Gastroesophageal reflux disease is a condition frequently associated
with esophagitis and motor abnormalities. Recent evidence suggests that proinflammatory …

The M2 muscarinic receptor mediates in vitro bladder contractions from patients with neurogenic bladder dysfunction

MA Pontari, AS Braverman… - American Journal of …, 2004 - journals.physiology.org
Bladder muscle specimens from seven patients with neurogenic bladder dysfunction were
analyzed to determine whether the muscarinic receptor subtype mediating contraction shifts …

Hypertrophy changes the muscarinic receptor subtype mediating bladder contraction from M3 toward M2

AS Braverman, MR Ruggieri Sr - American Journal of …, 2003 - journals.physiology.org
Major pelvic ganglion electrocautery (MPGE) and spinal cord injury in the rat induce bladder
hypertrophy and a change in muscarinic receptor subtypes mediating bladder contraction …

NF-κB activation by oxidative stress and inflammation suppresses contractility in colonic circular smooth muscle cells

XZ Shi, PF Lindholm, SK Sarna - Gastroenterology, 2003 - Elsevier
BACKGROUND & AIMS:: Transcription factor nuclear factor κB (NF-κB) plays a critical role in
transcriptional changes in several diseases, including inflammation. The aim of this study …

The intracellular pathway of the acetylcholine‐induced contraction in cat detrusor muscle cells

JY An, HS Yun, YP Lee, SJ Yang… - British journal of …, 2002 - Wiley Online Library
The present study was aimed to investigate intracellular pathways involved in acetylcholine
(ACh)‐induced contraction in cat detrusor muscle cells Contraction was expressed as per …

Signal transduction in esophageal and LES circular muscle contraction.

KM Harnett, W Cao, N Kim, UD Sohn… - The Yale Journal of …, 1999 - ncbi.nlm.nih.gov
Contraction of normal esophageal circular muscle (ESO) in response to acetylcholine (ACh)
is linked to M2 muscarinic receptors activating at least three intracellular phospholipases, ie …

Over-expression of the truncated ghrelin receptor polypeptide attenuates the constitutive activation of phosphatidylinositol-specific phospholipase C by ghrelin …

KM Chu, KBS Chow, PK Leung, PN Lau… - The international journal …, 2007 - Elsevier
In addition to regulating growth hormone release from the pituitary, ghrelin receptors also
influence cell proliferation and apoptosis. By studying mitogen-activated protein kinase …

Altered ion channel activity in murine colonic smooth muscle myocytes in an experimental colitis model

HI Akbarali, C Pothoulakis, I Castagliuolo - Biochemical and biophysical …, 2000 - Elsevier
We have investigated the activity of calcium and potassium channels in a murine model of
experimental colitis. Colonic myocytes from dextran sulphate sodium (DSS)-treated mice …

Multiple signaling pathways regulate FGF-2-induced retinal ganglion cell neurite extension and growth cone guidance

CA Webber, YY Chen, CL Hehr, J Johnston… - Molecular and Cellular …, 2005 - Elsevier
Growth cones use cues in their environment in order to grow in a directed fashion to their
targets. In Xenopus laevis, fibroblast growth factors (FGFs) participate in retinal ganglion cell …