Multiscale simulations of biological membranes: the challenge to understand biological phenomena in a living substance
Biological membranes are tricky to investigate. They are complex in terms of molecular
composition and structure, functional over a wide range of time scales, and characterized by …
composition and structure, functional over a wide range of time scales, and characterized by …
[HTML][HTML] Tear film lipid layer: A molecular level view
L Cwiklik - Biochimica et Biophysica Acta (BBA)-Biomembranes, 2016 - Elsevier
Human cornea is covered by an aqueous tear film, and the outermost layer of the tear film is
coated by lipids. This so-called tear film lipid layer (TFLL) reduces surface tension of the tear …
coated by lipids. This so-called tear film lipid layer (TFLL) reduces surface tension of the tear …
Mechanism and determinants of amphipathic helix-containing protein targeting to lipid droplets
Cytosolic lipid droplets (LDs) are the main storage organelles for metabolic energy in most
cells. They are unusual organelles that are bounded by a phospholipid monolayer and …
cells. They are unusual organelles that are bounded by a phospholipid monolayer and …
Triglyceride lipolysis triggers liquid crystalline phases in lipid droplets and alters the LD proteome
Lipid droplets (LDs) are reservoirs for triglycerides (TGs) and sterol-esters (SEs), but how
these lipids are organized within LDs and influence their proteome remain unclear. Using in …
these lipids are organized within LDs and influence their proteome remain unclear. Using in …
Interdigitation between triglycerides and lipids modulates surface properties of lipid droplets
Intracellular lipid droplets (LDs) are the main cellular site of metabolic energy storage. Their
structure is unique inside the cell, with a core of esterified fatty acids and sterols, mainly …
structure is unique inside the cell, with a core of esterified fatty acids and sterols, mainly …
Time‐Resolved Fluorescence Anisotropy of a Molecular Rotor Resolves Microscopic Viscosity Parameters in Complex Environments
Understanding viscosity in complex environments remains a largely unanswered question
despite its importance in determining reaction rates in vivo. Here, time‐resolved …
despite its importance in determining reaction rates in vivo. Here, time‐resolved …
Role of lipids in spheroidal high density lipoproteins
T Vuorela, A Catte, PS Niemelä, A Hall… - PLoS computational …, 2010 - journals.plos.org
We study the structure and dynamics of spherical high density lipoprotein (HDL) particles
through coarse-grained multi-microsecond molecular dynamics simulations. We simulate …
through coarse-grained multi-microsecond molecular dynamics simulations. We simulate …
Hepatic cholesterol biosynthesis and dioxin-induced dysregulation: A multiscale computational approach
Humans are constantly exposed to lipophilic persistent organic pollutants (POPs) that
accumulate in fatty foods. Among the numerous POPs, dioxins, in particular 2, 3, 7, 8 …
accumulate in fatty foods. Among the numerous POPs, dioxins, in particular 2, 3, 7, 8 …
Molecular organization of the tear fluid lipid layer
P Kulovesi, J Telenius, A Koivuniemi, G Brezesinski… - Biophysical journal, 2010 - cell.com
The tear fluid protects the corneal epithelium from drying out as well as from invasion by
pathogens. It also provides cell nutrients. Similarly to lung surfactant, it is composed of an …
pathogens. It also provides cell nutrients. Similarly to lung surfactant, it is composed of an …
The surface and hydration properties of lipid droplets
S Kim, JMJ Swanson - Biophysical Journal, 2020 - cell.com
Lipid droplets (LDs) are energy storage organelles composed of neutral lipids, such as
triacylglycerol (TG) and sterol esters, surrounded by a phospholipid (PL) monolayer. Their …
triacylglycerol (TG) and sterol esters, surrounded by a phospholipid (PL) monolayer. Their …