The endothelium, a monolayer of endothelial cells, constitutes the inner cellular lining of the
blood vessels (arteries, veins and capillaries) and the lymphatic system, and therefore is in …

Besides cyclooxygenase and NO-synthase, another distinct endothelial pathway,
endothelium-dependent hyperpolarization (EDHF), is involved in the relaxation of the …

Sepsis has a well-studied inflammatory phase, with a less-understood secondary
immunosuppressive phase. Elevated blood lactate and slow lactate clearance are …

Quercetin, a dietary antioxidant flavonoid, possesses strong anti-inflammatory and
cytoprotective activities. The effects were investigated in an animal model of …

The advances made in vascular biology in the last 25 years have considerably changed the
perception that one could have of the endothelial cells. Once considered as a diffusion …

Shock is characterized with vascular hyporesponsiveness to vasoconstrictors, thereby to
cause refractory hypotension, insufficient tissue perfusion, and multiple organ dysfunction …

Background—During septic shock, the vasoconstrictor response to norepinephrine is
seriously blunted. Animal experiments suggest that hyperpolarization of smooth muscle cells …

The endothelium controls vascular tone by releasing various vasoactive substances.
Additionally, another pathway associated with the hyperpolarization of both endothelial and …

Indoleamine 2, 3-dioxygenase (IDO) and the tryptophan–kynurenine pathway (TRP-KP) are
upregulated in ageing and could be implicated in the pathogenesis of delirium. This study …

Objective We aimed to broaden our understanding of a potential interaction between B1R
and TLR4, considering earlier studies suggesting that lipopolysaccharide (LPS) may trigger …