Objective The most widely studied positron emission tomography ligand for in vivo β‐
amyloid imaging is 11C‐Pittsburgh compound B (11C‐PIB). Its availability, however, is …

In Alzheimer's disease (AD), the deposition of β-amyloid (Aβ) is hypothesized to result in a
series of secondary neurodegenerative processes, leading ultimately to synaptic dysfunction …

2-((1 E, 3 E)-4-(6-(11C-methylamino) pyridin-3-yl) buta-1, 3-dienyl) benzo [d] thiazol-6-ol
(11C-PBB3) is a clinically useful PET probe that we developed for in vivo imaging of tau …

We have characterized the biodistribution and dosimetry of 18F-3′-F-6-OH-BTA1 (18F-
GE067), a newly developed radioligand to visualize and quantify amyloid burden, in healthy …

INTRODUCTION: Carbon-11-labelled positron emission tomography (PET) tracers
commonly used in biomedical research expose subjects to ionising radiation. Dosimetry is …

PET studies with biomarkers of regional neuronal activity (cerebral glucose metabolism or
blood flow [CBF]) and amyloid-β (Aβ) depositions provide complementary information for the …

Purpose Drugs promoting myelin repair represent a promising therapeutic approach in
multiple sclerosis and several candidate molecules are currently being evaluated, fostering …

Purpose To investigate the utility of Pittsburgh compound B (PiB) positron emission
tomography (PET) imaging for evaluating whole-body amyloid involvement in patients with …

The standardized uptake value ratio (SUVR, or summed tissue ratio) has been used
effectively in Pittsburgh compound B (PiB) PET studies to distinguish subjects who have …

Purpose There is urgent need for non‐invasive diagnostic biomarkers in the preclinical
phase of Alzheimer's Disease (AD). Several studies suggest that retinal thickness is reduced …