Immunosequencing identifies signatures of cytomegalovirus exposure history and HLA-mediated effects on the T cell repertoire
An individual's T cell repertoire dynamically encodes their pathogen exposure history. To
determine whether pathogen exposure signatures can be identified by documenting public T …
determine whether pathogen exposure signatures can be identified by documenting public T …
The aging bone marrow and its impact on immune responses in old age
T Pritz, B Weinberger, B Grubeck-Loebenstein - Immunology Letters, 2014 - Elsevier
With aging the immune system undergoes significant age-related changes. These age-
dependent changes are referred to as immunosenescence and are partially responsible for …
dependent changes are referred to as immunosenescence and are partially responsible for …
The response of autologous T cells to a human melanoma is dominated by mutated neoantigens
V Lennerz, M Fatho, C Gentilini… - Proceedings of the …, 2005 - National Acad Sciences
Our understanding of pathways leading to antitumor immunity may depend on an
undistorted knowledge of the primary antigenic targets of patients' autologous T cell …
undistorted knowledge of the primary antigenic targets of patients' autologous T cell …
Adoptive cellular therapy for early cytomegalovirus infection after allogeneic stem-cell transplantation with virus-specific T-cell lines
Adoptive transfer of CMV-specific T cells offers the potential for reconstitution of viral
immunity after allogeneic transplantation. However, the logistics of producing virus-specific T …
immunity after allogeneic transplantation. However, the logistics of producing virus-specific T …
CD8 coreceptor engagement of MR1 enhances antigen responsiveness by human MAIT and other MR1-reactive T cells
Mucosal-associated invariant T (MAIT) cells detect microbial infection via recognition of
riboflavin-based antigens presented by the major histocompatibility complex class I (MHC-I) …
riboflavin-based antigens presented by the major histocompatibility complex class I (MHC-I) …
T cell receptor profiling in type 1 diabetes
Abstract Purpose of Review The genetic susceptibility and dominant protection for type 1
diabetes (T1D) associated with human leukocyte antigen (HLA) haplotypes, along with …
diabetes (T1D) associated with human leukocyte antigen (HLA) haplotypes, along with …
Sequence and structural analyses reveal distinct and highly diverse human CD8+ TCR repertoires to immunodominant viral antigens
A diverse T cell receptor (TCR) repertoire is essential for controlling viral infections.
However, information about TCR repertoires to defined viral antigens is limited. We …
However, information about TCR repertoires to defined viral antigens is limited. We …
Selection of T cell clones expressing high-affinity public TCRs within Human cytomegalovirus-specific CD8 T cell responses
L Trautmann, M Rimbert, K Echasserieau… - The Journal of …, 2005 - journals.aai.org
Assessment of clonal diversity of T cell responses against human CMV (HCMV), a major
cause of morbidity in immunodepressed patients, provides important insights into the …
cause of morbidity in immunodepressed patients, provides important insights into the …
Human bone marrow hosts polyfunctional memory CD4+ and CD8+ T cells with close contact to IL-15–producing cells
D Herndler-Brandstetter, K Landgraf… - The Journal of …, 2011 - journals.aai.org
Recently, a key role in memory T cell homing and survival has been attributed to the bone
marrow (BM) in mice. In the human BM, the repertoire, function, and survival niches of CD4+ …
marrow (BM) in mice. In the human BM, the repertoire, function, and survival niches of CD4+ …
Immune evasion proteins of human cytomegalovirus do not prevent a diverse CD8+ cytotoxic T-cell response in natural infection
TJ Manley, L Luy, T Jones, M Boeckh, H Mutimer… - Blood, 2004 - ashpublications.org
Although cytomegalovirus (CMV) expresses proteins that interfere with antigen presentation
by class I major histocompatibility complex (MHC) molecules, CD8+ cytotoxic T cells (CTLs) …
by class I major histocompatibility complex (MHC) molecules, CD8+ cytotoxic T cells (CTLs) …