In the last ten years, there has been a dramatic surge in the number of publications where
single or groups of cells are grown in substrata that have elements of basement membrane …

Sphere-forming assays have been widely used to retrospectively identify stem cells based
on their reported capacity to evaluate self-renewal and differentiation at the single-cell level …

Most current research on human brain tumors is focused on the molecular and cellular
analysis of the bulk tumor mass. However, there is overwhelming evidence in some …

Neural stem cells exist not only in the developing mammalian nervous system but also in the
adult nervous system of all mammalian organisms, including humans. Neural stem cells can …

During the development of the mammalian central nervous system, neural stem cells and
their derivative progenitor cells generate neurons by asymmetric and symmetric divisions …

Although the existence of mammary stem cells has been suggested by serial transplantation
studies in mice, their identification has been hindered by the lack of specific surface markers …

Transformed stem cells have been isolated from some human cancers. We report that,
unlike other brain cancers, the lethal glioblastoma multiforme contains neural precursors …

Cortical development depends on the active integration of cell-autonomous and extrinsic
cues, but the coordination of these processes is poorly understood. Here, we show that the …

With the number of deaths due to stroke decreasing, more individuals are forced to live with
crippling disability resulting from the stroke. To date, no therapeutics exist after the first 4.5 h …

The objective of this study was to identify and characterize a self-renewing subpopulation of
human ovarian tumor cells (ovarian cancer-initiating cells, OCICs) fully capable of serial …