The Tribbles (TRIB) pseudokinases control multiple aspects of eukaryotic cell biology and
evolved unique features distinguishing them from all other protein kinases. The atypical …

The pseudokinase complement of the human kinase superfamily consists of approximately
60 signaling proteins, which lacks one or more of the amino acids typically required to …

Recent studies of proteins containing kinase-like domains that lack catalytic residue (s)
classically required for phosphotransfer, termed pseudokinases, have uncovered important …

The human Tribbles (TRB)-related pseudokinases are CAMK (calcium/calmodulin-
dependent protein kinase)-related family members that have evolved a series of highly …

The pseudokinase TRIB1 controls cell function in a range of contexts, by regulating MAP
kinase activation and mediating protein degradation via the COP1 ubiquitin ligase. TRIB1 …

Parkinson's disease (PD) is characterized by the progressive loss of select neuronal
populations, but the prodeath genes mediating the neurodegenerative processes remain to …

Expression of the Notch ligand JAG1 and Notch pathway activation promote poor prognosis,
basal-like breast cancer. We have recently shown that the pseudokinase Tribbles homolog 3 …

ABSTRACT Enterovirus A71 (EV-A71) is the main pathogen causing hand, foot and mouth
disease (HFMD) in children and occasionally associated with neurological diseases such as …

Cellular senescence is a complex process characterized by irreversible cell cycle arrest.
Senescent cells accumulate with age, promoting disease development, yet the absence of …

Eosinophils and neutrophils are critical for host defense, yet gaps in understanding how
granulocytes differentiate from hematopoietic stem cells (HSCs) into mature effectors …