Cyclin-dependent kinases (CDKs) are protein kinases characterized by needing a separate
subunit-a cyclin-that provides domains essential for enzymatic activity. CDKs play important …

Cyclin-dependent kinase 2 (CDK2) drives the progression of cells into the S-and M-phases
of the cell cycle. CDK2 activity is largely dispensable for normal development, but it is …

ABSTRACT CTSD/CathD/CATD (cathepsin D) is a lysosomal aspartic protease. A
distinguishing characteristic of CTSD is its dual functions of promoting cell proliferation via …

Holometabolous insects stop feeding at the final larval instar stage and then undergo
metamorphosis; however, the mechanism is unclear. In the present study, using the serious …

The regulation of glycometabolism homeostasis is vital to maintain health and development
of animal and humans; however, the molecular mechanisms by which organisms regulate …

A heterodimeric complex of two nuclear receptors, the ecdysone receptor (ECR) and
ultraspiracle (USP), transduces 20-hydroxyecdysone (20E) signaling to modulate insect …

G protein-coupled receptors (GPCRs) are cell membrane receptors for various ligands.
Recent studies have suggested that GPCRs transmit animal steroid hormone signals …

Insulin inhibits transcription factor Forkhead box O (FoxO) activity, and the steroid hormone
20-hydroxyecdysone (20E) activates FoxO; however, the mechanism is unclear. We …

Cyclin-dependent kinases (CDKs) are key players in cell cycle regulation and transcription.
The CDK-family member Cdk10 is important for neural development and can act as a …

In addition to the classical nuclear receptor pathway, there is a nongenomic pathway in the
cell membrane that regulates gene expression in animal steroid hormone signaling; …