Autism spectrum disorder (ASD) has a major impact on the development and social
integration of affected individuals and is the most heritable of psychiatric disorders. An …

Adult cortical areas consist of specialized cell types and circuits that support unique higher-
order cognitive functions. How this regional diversity develops from an initially uniform …

Imbalances between excitation and inhibition in synaptic transmission and neural circuits
have been implicated in autism spectrum disorders. Excitation and inhibition imbalances are …

The structure of neuronal circuits that subserve cognitive functions in the brain is shaped
and refined throughout development and into adulthood. Evidence from human and animal …

Autism spectrum disorder (ASD) is a set of neurodevelopmental disorders with a high
prevalence and impact on society. ASDs are characterized by deficits in both social behavior …

Autism spectrum disorder (ASD) is thought to result from deviation from normal development
of neural circuits and synaptic function. Many genes with mutation in ASD patients have …

Understanding the mechanisms underlying autism spectrum disorders (ASDs) is a
challenging goal. Here we review recent progress on several fronts, including genetics …

A biological understanding of the apparent sex bias in autism is lacking. Here we have
identified Cntnap2 KO mice as a model system to help better understand this dimorphism …

Autism spectrum disorder (ASD) is comprised of several conditions characterized by
alterations in social interaction, communication, and repetitive behaviors. Genetic and …

Mental disorders represent common brain diseases characterized by substantial
impairments of social and cognitive functions. The neurobiological causes and mechanisms …