Natural killer (NK) cells and CD8+ T cells can clear infected and transformed cells and
generate tolerance to themselves, which also prevents autoimmune diseases. Natural killer …

Identifying druggable binding sites on proteins is an important and challenging problem,
particularly for cryptic, allosteric binding sites that may not be obvious from X-ray, cryo-EM …

C‐type lectins are a large superfamily of proteins involved in a multitude of biological
processes. In particular, their involvement in immunity and homeostasis has rendered them …

Natural killer group 2D (NKG2D) is a homodimeric activating immunoreceptor whose
function is to detect and eliminate compromised cells upon binding to the NKG2D ligands …

The characterization of cryptic pockets has been elusive, despite substantial efforts.
Computational modeling approaches, such as molecular dynamics (MD) simulations, can …

The revolutionary progress in cancer immunotherapy, particularly the advent of immune
checkpoint inhibitors, marks a significant milestone in the fight against malignancies …

ABSTRACT A tetravalent peptide with the functional sequence NPSHPLSG designated
svH1C, binds with high avidity to lectin-type receptors specific for structures that contain …