Coagulation and fibrinolysis in diabetes

SH Alzahrani, RA Ajjan - Diabetes and Vascular Disease …, 2010 - journals.sagepub.com
Atherothrombotic complications are the main cause of mortality in subjects with diabetes.
Premature atherosclerosis, increased platelet reactivity and activation of coagulation factors …

Hypofibrinolysis in diabetes: a therapeutic target for the reduction of cardiovascular risk

K Kearney, D Tomlinson, K Smith, R Ajjan - Cardiovascular diabetology, 2017 - Springer
An enhanced thrombotic environment and premature atherosclerosis are key factors for the
increased cardiovascular risk in diabetes. The occlusive vascular thrombus, formed …

Light, medium-weight, or heavy? The nature of the first supermassive black hole seeds

F Sassano, R Schneider, R Valiante… - Monthly Notices of …, 2021 - academic.oup.com
Observations of hyper-luminous quasars at z> 6 reveal the rapid growth of supermassive
black holes (SMBHs) whose origin is still difficult to explain. Their progenitors may have …

Fibrin (ogen) and thrombotic disease

RAS Ariëns - Journal of Thrombosis and Haemostasis, 2013 - Wiley Online Library
Fibrinogen is an abundant plasma protein that, when converted to fibrin by thrombin,
provides the main building blocks for the clot. Dys‐, a‐, and hypo‐fibrinogenemias have …

Effects of diabetes on myocardial infarct size and cardioprotection by preconditioning and postconditioning

T Miki, T Itoh, D Sunaga, T Miura - Cardiovascular diabetology, 2012 - Springer
In spite of the current optimal therapy, the mortality of patients with ischemic heart disease
(IHD) remains high, particularly in cases with diabetes mellitus (DM) as a co-morbidity …

Diabetes is associated with posttranslational modifications in plasminogen resulting in reduced plasmin generation and enzyme-specific activity

RA Ajjan, T Gamlen, KF Standeven… - Blood, The Journal …, 2013 - ashpublications.org
Diabetes is associated with hypofibrinolysis by mechanisms that are only partially
understood. We investigated the effects of in vivo plasminogen glycation on fibrinolysis …

Short-and long-term mortality after myocardial infarction in patients with and without diabetes: changes from 1985 to 2008

ST Nauta, JW Deckers, KM Akkerhuis… - Diabetes …, 2012 - Am Diabetes Assoc
OBJECTIVE To study temporal trends in short-and long-term outcome after myocardial
infarction (MI) according to diabetes status. RESEARCH DESIGN AND METHODS We …

Diabetes and cardiovascular disease: pathophysiology of a life-threatening epidemic

RJ King, PJ Grant - Herz, 2016 - search.proquest.com
Diabetes is associated with the development of premature cardiovascular disease (CVD),
which relates to the clustering of risk factors such as dyslipidaemia, hypertension, obesity …

[HTML][HTML] Aggravated postinfarct heart failure in type 2 diabetes is associated with impaired mitophagy and exaggerated inflammasome activation

TD Devi, M Babu, P Mäkinen, MU Kaikkonen… - The American journal of …, 2017 - Elsevier
Type 2 diabetes mellitus (T2DM) is a major risk factor for heart disease. Mortality rates after
myocardial infarction (MI) are significantly increased in T2DM patients because of …

Effects of insulin resistance on endothelial progenitor cells and vascular repair

RM Cubbon, MB Kahn, SB Wheatcroft - Clinical Science, 2009 - portlandpress.com
Insulin resistance, a key feature of obesity, the metabolic syndrome and Type 2 diabetes
mellitus, results in an array of metabolic and vascular phenomena which ultimately promote …