Human brain organoids provide unique platforms for modeling several aspects of human
brain development and pathology. However, current brain organoid systems mostly lack the …

Despite the immense progress in genetics and cell biology, major knowledge gaps remain
with respect to prediction and control of the global morphologies that will result from the …

Cranial neural crest (NC) contributes to the developing vertebrate eye. By multidimensional,
quantitative imaging, we traced the origin of the ocular NC cells to two distinct NC …

The thalamus acts as a central integrator for processing and relaying sensory and motor
information to and from the cerebral cortex, and the habenula plays pivotal roles in emotive …

Background Cadmium is a nonessential toxic heavy metal, which enters the body easily and
damages the cellular system. The sonic hedgehog (Shh) signaling pathway is one of the key …

Thalamocortical axons (TCAs) cross several tissues on their journey to the cortex.
Mechanisms must be in place along the route to ensure they connect with their targets in an …

Glioma is a major brain tumor, and the associated mortality rate is very high. Contemporary
therapies provide a chance of survival for 9–12 months. Therefore, a novel approach is …

The thalamocortical projections are part of the most important higher level processing
connections in the vertebrates and follow a highly ordered pathway from their origin in the …

Abstract [eng] Genomic editing of cell lines is essential in developmental biology, disease
modelling and clinical research. However, usually, only one or a few genes are edited in the …

Pax6 is a well-known regulator of early neuroepithelial progenitor development. Its
constitutive loss has a particularly strong effect on the developing prethalamus, causing it to …