Twenty years of anti-vascular endothelial growth factor therapeutics in neovascular age-related macular degeneration treatment

BH Moon, Y Kim, SY Kim - International Journal of Molecular Sciences, 2023 - mdpi.com
Neovascular age-related macular degeneration (nAMD) is the primary disastrous retinal
disease that leads to blindness in the elderly population. In the early 2000s, nAMD resulted …

AAV-based strategies for treatment of retinal and choroidal vascular diseases: advances in age-related macular degeneration and diabetic retinopathy therapies

BFM Castro, JC Steel, CJ Layton - BioDrugs, 2024 - Springer
Age-related macular degeneration (AMD) and diabetic retinopathy (DR) are vascular
diseases with high prevalence, ranking among the leading causes of blindness and vision …

The different facades of retinal and choroidal endothelial cells in response to hypoxia

E Alizadeh, P Mammadzada, H André - International journal of molecular …, 2018 - mdpi.com
Ocular angiogenic diseases, such as proliferative diabetic retinopathy and neovascular age-
related macular degeneration, are associated with severe loss of vision. These pathologies …

A novel antitumor strategy: simultaneously inhibiting angiogenesis and complement by targeting VEGFA/PIGF and C3b/C4b

H Wang, Y Li, G Shi, Y Wang, Y Lin, Q Wang… - Molecular Therapy …, 2020 - cell.com
Therapeutic antibodies targeting vascular endothelial growth factor (VEGF) have become a
critical regimen for tumor therapy, but the efficacy of monotherapy is usually limited by drug …

[HTML][HTML] VEGF—Virus Interactions: Pathogenic Mechanisms and Therapeutic Applications

C Sánchez-Martínez, E Grueso, T Calvo-López… - Cells, 2024 - mdpi.com
Many types of viruses directly or indirectly target the vascular endothelial growth factor
(VEGF) system, which is a central regulator of vasculogenesis and angiogenesis in …

AAV-mediated gene therapies for glaucoma and uveitis: are we there yet?

B Castro, JC Steel, CJ Layton - Expert Reviews in Molecular …, 2024 - cambridge.org
Glaucoma and uveitis are non-vascular ocular diseases which are among the leading
causes of blindness and visual loss. These conditions have distinct characteristics and …

Identifying mouse autoimmune uveitis from fundus photographs using deep learning

J Sun, X Huang, C Egwuagu, Y Badr… - … Vision Science & …, 2020 - tvst.arvojournals.org
Purpose: To develop a deep learning model for objective evaluation of experimental
autoimmune uveitis (EAU), the animal model of posterior uveitis that reveals its essential …

Silencing fibroblast growth factor 7 inhibits krypton laser‐induced choroidal neovascularization in a rat model

C Zhang, M Han, S Wu - Journal of Cellular Biochemistry, 2019 - Wiley Online Library
Choroidal neovascularization (CNV), a characteristic of age‐related macular degeneration,
is an underlying cause of severe vision loss among elderly patients. Fibroblast growth factor …

Novel Approaches to the Treatment of Noninfectious Uveitis

JR Smith - Treatment of Non-infectious Uveitis, 2019 - Springer
Conventional immunosuppressive drugs are effective treatment for some, but not all,
patients with noninfectious uveitis. An additional consideration in the use of these drugs is …