Epileptogenesis is a chronic process that can be triggered by genetic or acquired factors,
and that can continue long after epilepsy diagnosis. In 2015, epileptogenesis is not a …

Epilepsy is a complex neurological syndrome characterized by seizures resulting from
neuronal hyperexcitability and sudden and synchronized bursts of electrical discharges …

The induction of cellular reprogramming via expression of the transcription factors Oct4,
Sox2, Klf4 and c‐Myc (OSKM) can drive dedifferentiation of somatic cells and ameliorate …

Impaired activation and regulation of the extinction of inflammatory cells and molecules in
injured neuronal tissues are key factors in the development of epilepsy. SerpinA3N is mainly …

Prevention of epileptogenesis after brain trauma is an unmet medical challenge. Recent
molecular profiling studies have provided an insight into molecular changes that contribute …

The dentate gyrus is hypothesized to function as a" gate," limiting the flow of excitation
through the hippocampus. During epileptogenesis, adult-generated granule cells (DGCs) …

Aging is associated with reductions in hippocampal volume that are accelerated by
Alzheimer's disease and vascular risk factors. Our genome-wide association study (GWAS) …

The phosphatidylinositol-3-kinase/phosphatase and tensin homolog (PTEN)-mammalian
target of rapamycin (mTOR) pathway regulates a variety of neuronal functions, including cell …

Background The expression pattern and function of miRNAs in the rat model of temporal
lobe epilepsy have not been well defined. Profiling miRNA expression in the rat model of …

Maintaining average activity within a set-point range constitutes a fundamental property of
central neural circuits. However, whether and how activity set points are regulated remains …