Abstract Indoleamine 2, 3-dioxygenase (IDO) as a principle enzyme in tryptophan (Trp)
catabolism, modulates immune responses and promotes cancer progression. In recent …

Damage-associated molecular patterns (DAMPs) are danger signals (or alarmins) alerting
immune cells through pattern recognition receptors (PRRs) to begin defense activity …

The tumor microenvironment affects the outcome of radiotherapy against head and neck
squamous cell carcinoma (HNSCC). We recently found that tolerogenic myeloid cells …

Photodynamic therapy (PDT) not only kills tumor cells directly but also rapidly recruits and
activates immune cells favoring the development of antitumor adaptive immunity. It is …

It is believed that pathways of the immune system are responsible for eradicating cancer
cells; however, their over-activation and also their ectopic expression in tumor cells and …

Tumor-associated macrophages (TAMs) are the essential components of the tumor
microenvironment. TAMs originate from blood monocytes and undergo pro-or anti …

Aim: We investigated a promising cooperative combination of radiotherapy (RT) and
programmed death ligand 1 (PD-L1) monoclonal antibodies (mAb) in both local and …

A comment on this article appears in" The future of rectal cancer: let's do the right trials." J
Clin Oncol. 2011 Oct 20; 29 (30): 4057-9; author reply 4059-61. A comment on this article …

I am indebted to Prof. Theofilos Poutahidis for his valuable insight on a vital part of this work,
providing access to his laboratory and for the manual labour and time he dedicated in the …

Immune response to cancer is a dynamic process in which uncontrolled growth of cancer
cells is countered by various protective mechanisms. However, the progression of the …