Advancing cell therapy for neurodegenerative diseases

S Temple - Cell stem cell, 2023 - cell.com
Cell-based therapies are being developed for various neurodegenerative diseases that
affect the central nervous system (CNS). Concomitantly, the roles of individual cell types in …

Development of the Binocular Circuit

E Herrera, A Chédotal, C Mason - Annual review of …, 2024 - annualreviews.org
Seeing in three dimensions is a major property of the visual system in mammals. The circuit
underlying this property begins in the retina, from which retinal ganglion cells (RGCs) extend …

High-density electrode recordings reveal strong and specific connections between retinal ganglion cells and midbrain neurons

J Sibille, C Gehr, JI Benichov… - Nature …, 2022 - nature.com
The superior colliculus is a midbrain structure that plays important roles in visually guided
behaviors in mammals. Neurons in the superior colliculus receive inputs from retinal …

Mapping visual functions onto molecular cell types in the mouse superior colliculus

Y Liu, EL Savier, VJ DePiero, C Chen, DC Schwalbe… - Neuron, 2023 - cell.com
The superficial superior colliculus (sSC) carries out diverse roles in visual processing and
behaviors, but how these functions are delegated among collicular neurons remains …

Transcriptomic cell-type specificity of local cortical circuits

M Patiño, MA Rossa, WN Lagos, NS Patne… - Neuron, 2024 - cell.com
Complex neocortical functions rely on networks of diverse excitatory and inhibitory neurons.
While local connectivity rules between major neuronal subclasses have been established …

[HTML][HTML] Osteopontin drives retinal ganglion cell resiliency in glaucomatous optic neuropathy

M Zhao, K Toma, B Kinde, L Li, AK Patel, KY Wu… - Cell reports, 2023 - cell.com
Chronic neurodegeneration and acute injuries lead to neuron losses via diverse processes.
We compared retinal ganglion cell (RGC) responses between chronic glaucomatous …

Predation without direction selectivity

J Krizan, X Song, MJ Fitzpatrick… - Proceedings of the …, 2024 - National Acad Sciences
Across the animal kingdom, visual predation relies on motion-sensing neurons in the
superior colliculus (SC) and its orthologs. These neurons exhibit complex stimulus …

A genetically defined tecto-thalamic pathway drives a system of superior-colliculus-dependent visual cortices

JM Brenner, R Beltramo, CR Gerfen, S Ruediger… - Neuron, 2023 - cell.com
Cortical responses to visual stimuli are believed to rely on the geniculo-striate pathway.
However, recent work has challenged this notion by showing that responses in the …

[HTML][HTML] Astrocyte heterogeneity within white matter tracts and a unique subpopulation of optic nerve head astrocytes

AG Mazumder, AM Julé, PF Cullen, D Sun - Iscience, 2022 - cell.com
Much of what we know about astrocyte form and function is derived from the study of gray
matter protoplasmic astrocytes, whereas white matter fibrous astrocytes remain relatively …

Toll‐like receptor 4‐mediated microglial inflammation exacerbates early white matter injury following experimental subarachnoid hemorrhage

J Peng, Y Xie, J Pang, Y Wu, J Zhou… - Journal of …, 2023 - Wiley Online Library
Neuroinflammation has been reported to be associated with white matter injury (WMI) after
subarachnoid hemorrhage (SAH). As the main resident immune cells of the brain, microglia …