Interactions between the immune system and cancer: a brief review of non-spatial mathematical models

R Eftimie, JL Bramson, DJD Earn - Bulletin of mathematical biology, 2011 - Springer
We briefly review spatially homogeneous mechanistic mathematical models describing the
interactions between a malignant tumor and the immune system. We begin with the simplest …

On the foundations of cancer modelling: selected topics, speculations, and perspectives

N Bellomo, NK Li, PK Maini - Mathematical Models and Methods in …, 2008 - World Scientific
This paper presents a critical review of selected topics related to the modelling of cancer
onset, evolution and growth, with the aim of illustrating, to a wide applied mathematical …

A chaos study of tumor and effector cells in fractional tumor-immune model for cancer treatment

S Kumar, A Kumar, B Samet, JF Gómez-Aguilar… - Chaos, Solitons & …, 2020 - Elsevier
A tumor is most dangerous disease of medical science which is a mass or lumps of tissue
that's formed by an accumulation of abnormal cells. A famous fractional tumor-immune …

A validated mathematical model of cell-mediated immune response to tumor growth

LG de Pillis, AE Radunskaya, CL Wiseman - Cancer research, 2005 - AACR
Mathematical models of tumor-immune interactions provide an analytic framework in which
to address specific questions about tumor-immune dynamics. We present a new …

Insights into the kinetics of siRNA-mediated gene silencing from live-cell and live-animal bioluminescent imaging

DW Bartlett, ME Davis - Nucleic acids research, 2006 - academic.oup.com
Small interfering RNA (siRNA) molecules are potent effectors of post-transcriptional gene
silencing. Using noninvasive bioluminescent imaging and a mathematical model of siRNA …

Optimal control for cancer treatment mathematical model using Atangana–Baleanu–Caputo fractional derivative

NH Sweilam, SM Al-Mekhlafi, T Assiri… - Advances in Difference …, 2020 - Springer
In this work, optimal control for a fractional-order nonlinear mathematical model of cancer
treatment is presented. The suggested model is determined by a system of eighteen …

A cellular automata model of tumor–immune system interactions

DG Mallet, LG De Pillis - Journal of theoretical biology, 2006 - Elsevier
We present a hybrid cellular automata–partial differential equation model of moderate
complexity to describe the interactions between a growing tumor next to a nutrient source …

[HTML][HTML] Mathematical modeling of radiotherapy and its impact on tumor interactions with the immune system

RA Bekker, S Kim, S Pilon-Thomas, H Enderling - Neoplasia, 2022 - Elsevier
Radiotherapy is a primary therapeutic modality widely utilized with curative intent.
Traditionally tumor response was hypothesized to be due to high levels of cell death …

Quantitative systems pharmacology approaches for immuno‐oncology: adding virtual patients to the development paradigm

V Chelliah, G Lazarou, S Bhatnagar… - Clinical …, 2021 - Wiley Online Library
Drug development in oncology commonly exploits the tools of molecular biology to gain
therapeutic benefit through reprograming of cellular responses. In immuno‐oncology (IO) …

A mathematical model of tumor–immune interactions

M Robertson-Tessi, A El-Kareh, A Goriely - Journal of theoretical biology, 2012 - Elsevier
A mathematical model of the interactions between a growing tumor and the immune system
is presented. The equations and parameters of the model are based on experimental and …