Plakophilin3 (PKP3) loss results in increased transformation in multiple cell lines in vitro and
increased tumor formation in vivo. A microarray analysis performed in the PKP3 knockdown …

In the recent years, sequence-specific nucleases such as ZFNs, TALENs, and CRISPR/Cas9
have revolutionzed the fields of animal genome editing and transgenesis. However, these …

The epidermis is a stratified epithelium that functions as the first line of defense against
pathogenic invasion and acts as a barrier preventing water loss. In this study, we aimed to …

Infertility affects 10%–20% of the population in most countries, with approximately half of
those cases resulting from male infertility. Although millions of infertile men are able to have …

An increase in tumour formation and metastasis are observed upon plakophilin3 (PKP3)
loss. To identify pathways downstream of PKP3 loss that are required for increased tumour …

Abstract Plakophilin3 (PKP3) loss leads to tumor progression and metastasis of colon
cancer cells. The goal of this report was to determine if PKP3 loss led to increased disease …

Background Recombinant adeno-associated viruses (AAVs) are emerging as favoured
transgene delivery vectors for both research applications and gene therapy. In this context, a …

14‐3‐3 proteins are conserved, dimeric, acidic proteins that regulate multiple cellular
pathways. Loss of either 14‐3‐3ε or 14‐3‐3γ leads to centrosome amplification. However …

PICK1 (protein interacting with C-kinase 1) is a peripheral membrane protein with high
expression in brain, testis, pancreas and other neuroendocrine tissues. Male Pick1 knockout …

Transgenic technologies conventionally rely on the oocyte as a substrate for genetic
modification. Owing to their accessibility, however, male germ cells, including mature sperm …