Resveratrol and clinical trials: the crossroad from in vitro studies to human evidence

J Tomé-Carneiro, M Larrosa… - Current …, 2013 - benthamdirect.com
Resveratrol (3, 5, 4'-trihydroxy-trans-stilbene) is a non-flavonoid polyphenol that may be
present in a limited number of foodstuffs such as grapes and red wine. Resveratrol has been …

Neuroprotective phytochemicals in experimental ischemic stroke: mechanisms and potential clinical applications

H Xu, E Wang, F Chen, J Xiao… - Oxidative Medicine and …, 2021 - Wiley Online Library
Ischemic stroke is a challenging disease with high mortality and disability rates, causing a
great economic and social burden worldwide. During ischemic stroke, ionic imbalance and …

What is new for an old molecule? Systematic review and recommendations on the use of resveratrol

O Vang, N Ahmad, CA Baile, JA Baur, K Brown… - PloS one, 2011 - journals.plos.org
Background Resveratrol is a natural compound suggested to have beneficial health effects.
However, people are consuming resveratrol for this reason without having the adequate …

Preconditioning is hormesis part I: Documentation, dose-response features and mechanistic foundations

EJ Calabrese - Pharmacological Research, 2016 - Elsevier
This article provides the first extensive documentation of the dose response features of pre-
and postconditioning. Pre-and postconditioning studies with rigorous study designs, using …

Molecular mechanisms of the cardiovascular protective effects of polyphenols

R Andriantsitohaina, C Auger, T Chataigneau… - British Journal of …, 2012 - cambridge.org
Epidemiological studies have reported a greater reduction in cardiovascular risk and
metabolic disorders associated with diets rich in polyphenols. The antioxidant effects of …

Impact of microRNAs on ischemic stroke: from pre-to post-disease

G Li, KC Morris-Blanco, MS Lopez, T Yang… - Progress in …, 2018 - Elsevier
Stroke is the number one cause of neurological dysfunction in adults and has a heavy
socioeconomic burden worldwide. The etiological origins of ischemic stroke and resulting …

Resveratrol neuroprotection in stroke and traumatic CNS injury

MS Lopez, RJ Dempsey, R Vemuganti - Neurochemistry international, 2015 - Elsevier
Resveratrol, a stilbene formed in many plants in response to various stressors, elicits
multiple beneficial effects in vertebrates. Particularly, resveratrol was shown to have …

Nrf2/ARE pathway modulation by dietary energy regulation in neurological disorders

AR Vasconcelos, NB Dos Santos, C Scavone… - Frontiers in …, 2019 - frontiersin.org
Nuclear factor erythroid 2-related factor 2 (Nrf2) regulates the expression of an array of
enzymes with important detoxifying and antioxidant functions. Current findings support the …

Targeting endoplasmic reticulum stress using natural products in neurological disorders

A Jangra, M Verma, D Kumar, M Rachamalla… - Neuroscience & …, 2022 - Elsevier
The primary aim of this review is to summarize the literature on natural products that are
effective in the treatment of various neurological disorders by targeting endoplasmic …

Resveratrol protects CA1 neurons against focal cerebral ischemic reperfusion-induced damage via the ERK-CREB signaling pathway in rats

Z Li, F Fang, Y Wang, L Wang - Pharmacology Biochemistry and Behavior, 2016 - Elsevier
Ischemic stroke is a primary cause of mortality and disability in the aged population.
Resveratrol (Res), a natural polyphenol enriched in plants, presents diverse biological …