Obesity and nonalcoholic fatty liver disease: From pathophysiology to therapeutics

SA Polyzos, J Kountouras, CS Mantzoros - Metabolism, 2019 - Elsevier
The obesity epidemic is closely associated with the rising prevalence and severity of
nonalcoholic fatty liver disease (NAFLD): obesity has been linked not only with simple …

Intestinal microbiome and NAFLD: molecular insights and therapeutic perspectives

H Hu, A Lin, M Kong, X Yao, M Yin, H Xia, J Ma… - Journal of …, 2020 - Springer
Non-alcoholic fatty liver disease (NAFLD) is the hepatic manifestation of dysregulated lipid
and glucose metabolism, which is often associated with obesity, dyslipidemia and insulin …

[HTML][HTML] Effects of shenling baizhu powder herbal formula on intestinal microbiota in high-fat diet-induced NAFLD rats

Y Zhang, K Tang, Y Deng, R Chen, S Liang… - Biomedicine & …, 2018 - Elsevier
Background Worldwide, non-alcoholic fatty liver disease (NAFLD) is a common chronic liver
disease closely associated with obesity, diabetes and other metabolic diseases. Shenling …

Targeting gut microbiota as a possible therapy for mastitis

X Hu, S Li, Y Fu, N Zhang - European Journal of Clinical Microbiology & …, 2019 - Springer
Mastitis, a disease that affects both dairy herds and humans, is recognized as the most
common source of losses in the dairy industry. Antibiotics have been used for years as the …

Non-alcoholic fatty liver disease: a multi-system disease influenced by ageing and sex, and affected by adipose tissue and intestinal function

J Bilson, JK Sethi, CD Byrne - Proceedings of the Nutrition Society, 2022 - cambridge.org
In recent years, a wealth of factors are associated with increased risk of developing non-
alcoholic fatty liver disease (NAFLD) and NAFLD is now thought to increase the risk of …

Multiple organs involved in the pathogenesis of non-alcoholic fatty liver disease

X Li, H Wang - Cell & Bioscience, 2020 - Springer
Non-alcoholic fatty liver disease (NAFLD) represents the leading cause of chronic liver
disease worldwide and the anticipated health burden is huge. There are limited therapeutic …

Effect of sulfate group on sulfated polysaccharides-induced improvement of metabolic syndrome and gut microbiota dysbiosis in high fat diet-fed mice

S Wu, Y Liu, P Jiang, Y Xu, W Zheng, S Song… - International Journal of …, 2020 - Elsevier
Sulfated polysaccharides were shown to benefit metabolic syndrome (MS) and gut
microbiota, but the contribution of sulfate group remains unclear. In this study, sulfated …

Current and future treatment options in non-alcoholic steatohepatitis (NASH)

N Lazaridis, E Tsochatzis - Expert review of gastroenterology & …, 2017 - Taylor & Francis
Introduction: Non-alcoholic steatohepatitis (NASH) is a chronic liver disease that can
progress to cirrhosis and hepatocellular carcinoma. Diagnosis of NASH requires a liver …

[HTML][HTML] Uroguanylin prevents hepatic steatosis, mitochondrial dysfunction and fibrosis in obesity-associated NAFLD

EM Fernández-Sáez, M Losarcos, S Becerril, V Valentí… - Metabolism, 2023 - Elsevier
Background The biological mediators supporting the resolution of liver steatosis,
inflammation and fibrosis after bariatric surgery in patients with obesity and NAFLD remain …

Updated mechanisms of MASLD pathogenesis

Y Li, P Yang, J Ye, Q Xu, J Wu, Y Wang - Lipids in Health and Disease, 2024 - Springer
Metabolic dysfunction-associated steatotic liver disease (MASLD) has garnered
considerable attention globally. Changing lifestyles, over-nutrition, and physical inactivity …