The physiological balance between excitation and inhibition in the brain is significantly
affected in Alzheimer's disease (AD). Several neuroactive compounds and their signaling …

Alzheimer's disease (AD) is a progressive neurodegenerative disease. The accumulation of
amyloid-β (Aβ) plaques and tau neurofibrillary tangles are the key players responsible for …

There is growing evidence that membrane transporters expressed at the blood-brain barrier
(BBB) and brain parenchymal cells play an important role in Alzheimer's disease (AD) …

Neuroinflammation is an important feature in the pathogenesis and progression of central
nervous system (CNS) diseases including Alzheimer's disease (AD). One of the widely used …

Membrane transporters such as ATP-binding cassette (ABC) and solute carrier (SLC)
transporters expressed at the neurovascular unit (NVU) play an important role in drug …

Reduced activity of efflux transporter ABCG2, caused eg, by inhibition or decreased function
genetic variants, can increase drug absorption and plasma levels. ABCG2 has one clinically …

Peripheral contact to pathogen-associated molecular patterns (PAMPs) evokes a systemic
innate immune response which is rapidly relayed to the central nervous system (CNS). The …

Membrane transporters are important for maintaining brain homeostasis by regulating the
passage of solutes into, out of, and within the brain. Growing evidence suggests neurotoxic …

Triple negative breast cancer (TNBC) is among the most aggressive and deadly cancer
subtypes. Intra-tumoral hypoxia is associated with aggressiveness and drug resistance in …

Cytosolic phospholipase A2 (cPLA2) is an enzyme regulating membrane phospholipid
homeostasis and the release of arachidonic acid utilized in inflammatory responses. It …