In late 1993 and early 1994, two distinct lines of research converged on a new tumor
suppressor gene located on human chromosome 9p21. The órst report was of the existence …

Lung cancer is the most common cause of cancer death in developed countries. The
prognosis is poor, with less than 15% of patients surviving 5 years after diagnosis. The poor …

The present invention relates to the detection of nucleic acid sequence differences using
coupled ligase detection reaction and polymerase chain reaction. One aspect of the present …

Purpose: We determine the relative sensitivities of cytology and fluorescence in situ
hybridization (FISH) for the detection of urothelial carcinoma. Materials and Methods: A …

Cell cycle arrest at the G1 checkpoint allows completion of critical macromolecular events
prior to S phase. Regulators of the G1 checkpoint include an inhibitor of cyclin-dependent …

The purpose of this study was to develop a multitarget, multicolor fluorescence in situ
hybridization (FISH) assay for the detection of urothelial carcinoma (UC) in urine specimens …

Urothelial cancer has served as one of the most important sources of information about the
mutational events that underlie the development of human solid malignancies. Although …

Microsatellite instability has been reported to be an important feature of tumors from
hereditary nonpolyposis colorectal carcinoma (HNPCC) patients. The recent discovery of …

A critical area ofchromosomal loss at region 9p2 1-22 has been implicated in the genesis of
different types of primary tumors. Initial observations defined dele-tions of this region in …

WO 92/10588 6/1992 (EP). O 601714 A1 6/1994 (EP). WO 89/10977 11/1989 (WO). WO
90/15070 12/1990 (WO). WO 92/16655 10/1992 (WO). WO 93/17126 9/1993 (WO). WO …