Cell signaling in eukaryotes is an evolutionarily conserved mechanism to respond and
adapt to various environmental changes. In general, signal sensation is mediated by a …

In this study thiosemicarbazones derivatives of 5-[(trifluoromethyl) phenylthio]-2-furaldehyde
were synthesized and evaluated in terms of their efficiency in challenging the growth of …

Lipid droplets (LDs; lipid bodies) are intracellular sites of lipid storage and metabolism
present in all cell types. Eukaryotic LDs are involved in eicosanoid production during several …

Chagas heart disease, the leading cause of heart failure in Latin America, results from
infection with the parasite Trypanosoma cruzi. Although T. cruzi disseminates …

Chagas disease, caused by Trypanosoma cruzi, remains an important neglected disease
and a cause of significant morbidity and mortality. No longer confined to endemic areas of …

The lipid mediators, platelet‐activating factor (PAF) and lysophosphatidylcholine (LPC), play
relevant pathophysiological roles in Trypanosoma cruzi infection. Several species of LPC …

BACKGROUND The knowledge about eicosanoid metabolism and lipid droplet (LD)
formation in the Leishmania is very limited and new approaches are needed to identify …

Trogocytosis was originally thought to be restricted to the interaction of cells of the immune
system with cancer cells. Such membrane exchanges are probably a general process in cell …

The chronic indeterminate phase of Chagas' disease is asymptomatic despite positive test
results for antibodies specific to Trypanosoma cruzi. CD62P-APC (P-selectin) and PAC-1 …

The eicosanoid family includes prostanoids, leukotrienes, and other oxygenated derivatives.
Prostanoids are a major class of the eicosanoid family derived from metabolism of …