The functions, purposes, and roles of metallothioneins have been the subject of
speculations since the discovery of the protein over 60 years ago. This article guides …

Free radicals are chemical particles containing one or more unpaired electrons, which may
be part of the molecule. They cause the molecule to become highly reactive. The free …

The solution and complexation chemistry of zinc ions is the basis for zinc biology. In living
organisms, zinc is redox-inert and has only one valence state: Zn (II). Its coordination …

Alzheimer's disease (AD) 1− 3 is the most common form of dementia (estimated∼ 50− 60%
of all cases), associated with loss of memory (in particular episodic memory), cognitive …

Recent discoveries in zinc biology provide a new platform for discussing the primary
physiological functions of mammalian metallothioneins (MTs) and their exquisite zinc …

Higher eukaryotes' life is impossible without copper redox activity and, literally, every breath
we take biochemically demonstrates this. However, this dependence comes at a …

Zinc (II) ions are redox-inert in biology. Yet, their interaction with sulfur of cysteine in cellular
proteins can confer ligand-centered redox activity on zinc coordination sites, control protein …

The ability of zinc to retard oxidative processes has been recognized for many years. In
general, the mechanism of antioxidation can be divided into acute and chronic effects …

Zinc is one of the most abundant nutritionally essential elements in the human body. It is
found in all body tissues with 85% of the whole body zinc in muscle and bone, 11% in the …

▪ Abstract Metallothioneins (MT) are low-molecular-weight, cysteine-rich, metal-binding
proteins. MT genes are readily induced by various physiologic and toxicologic stimuli …