In medicine, nanotechnology has sparked a rapidly growing interest as it promises to solve a
number of issues associated with conventional therapeutic agents, including their poor …

Conspectus Since the US Food and Drug Administration (FDA) granted emergency use
authorization for two mRNA vaccines against SARS-CoV-2, mRNA-based technology has …

Safe and efficacious systemic delivery of messenger RNA (mRNA) to specific organs and
cells in vivo remains the major challenge in the development of mRNA-based therapeutics …

Loss-of-function mutations in Angiopoietin-like 3 (Angptl3) are associated with lowered
blood lipid levels, making Angptl3 an attractive therapeutic target for the treatment of human …

A central challenge to the development of protein-based therapeutics is the inefficiency of
delivery of protein cargo across the mammalian cell membrane, including escape from …

Biopharmaceuticals have emerged to play a vital role in disease treatment and have shown
promise in the rapidly expanding pharmaceutical market due to their high specificity and …

Herein we report a convenient chemical approach to reversibly modulate protein (RNase A)
function and develop a protein that is responsive to reactive oxygen species (ROS) for …

Lipid nanoparticle (LNP)-based drug delivery systems have become the most clinically
advanced non-viral delivery technology. LNPs can encapsulate and deliver a wide variety of …

An efficient and safe method to deliver active proteins into the cytosol of targeted cells is
highly desirable to advance protein‐based therapeutics. A novel protein delivery platform …

Conspectus The use of protein to precisely manipulate cell signaling is an effective
approach for controlling cell fate and developing precision medicine. More recently …