Alzheimer's disease (AD) affects an estimated 44 million individuals worldwide, yet no
therapeutic intervention is available to stop the progression of the dementia …

Apart from genetic and environmental factors, the mucosal immune system of the gut plays a
central role in the pathogenesis of inflammatory bowel disease (IBD). In the healthy gut, the …

T-cell immunoregulatory cytokines influence the persistence of hepatitis C virus (HCV)
chronic infection and the extent of liver damage. Th1 cytokines positively correlate with …

Inflammatory bowel diseases (IBD), encompassing both Crohn Disease (CD) and ulcerative
colitis (UC) are globally prevalent diseases, impacting children of all ages. The hallmark of …

The pathogenesis and treatment of inflammatory bowel disease (IBD) have been recently
advanced, while it is still challenged with high morbidity and poor prognosis. Infliximab, a …

Background Crohn's disease (CD) is a chronic inflammatory disease of the gastrointestinal
tract. Current medications have potentially serious side effects. Hence, there is increasing …

Aims Ursolic acid (UA), a natural pentacyclic triterpenoid acid, has been reported to show
immunomodulatory activity. This study investigated the effects of UA on nuclear factor-kappa …

Infliximab (Remicade®) is a chimeric monoclonal antibody against tumour necrosis factor
(TNF)-α that has shown efficacy in Crohn's disease and rheumatoid arthritis with a disease …

Crohn's disease (CD) is a chronic inflammatory disease of unknown etiology that covers the
entire digestive tract and occurs with periods of remission and clinical exacerbation. CD is …

A variety of biological processes are regulated by posttranslational modifications.
Posttranslational modifications including phosphorylation, ubiquitination, glycosylation, and …