Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018
L Galluzzi, I Vitale, SA Aaronson, JM Abrams… - Cell Death & …, 2018 - nature.com
Over the past decade, the Nomenclature Committee on Cell Death (NCCD) has formulated
guidelines for the definition and interpretation of cell death from morphological, biochemical …
guidelines for the definition and interpretation of cell death from morphological, biochemical …
Caspases and their substrates
Protease biology is intimately linked to the functional consequences of substrate cleavage
events. Human caspases are a family of 12 fate-determining cysteine proteases that are best …
events. Human caspases are a family of 12 fate-determining cysteine proteases that are best …
Synaptic impairment in Alzheimer's disease: a dysregulated symphony
Alzheimer's disease (AD) is characterized by memory loss, cognitive decline, and
devastating neurodegeneration, not only as a result of the extracellular accumulation of beta …
devastating neurodegeneration, not only as a result of the extracellular accumulation of beta …
Deorphanizing caspase-3 and caspase-9 substrates in and out of apoptosis with deep substrate profiling
Caspases are a family of enzymes that regulate biological processes such as inflammation
and programmed cell death, through proteolysis. For example, in the intrinsic pathway of …
and programmed cell death, through proteolysis. For example, in the intrinsic pathway of …
A cell's fate: an overview of the molecular biology and genetics of apoptosis
GC Cavalcante, AP Schaan, GF Cabral… - International journal of …, 2019 - mdpi.com
Apoptosis is one of the main types of regulated cell death, a complex process that can be
triggered by external or internal stimuli, which activate the extrinsic or the intrinsic pathway …
triggered by external or internal stimuli, which activate the extrinsic or the intrinsic pathway …
Apoptosis and clearance of apoptotic cells
S Nagata - Annual review of immunology, 2018 - annualreviews.org
The human body generates 10–100 billion cells every day, and the same number of cells
die to maintain homeostasis in our body. Cells infected by bacteria or viruses also die. The …
die to maintain homeostasis in our body. Cells infected by bacteria or viruses also die. The …
AND-gate contrast agents for enhanced fluorescence-guided surgery
Surgical resection of tumours requires precisely locating and defining the margins between
lesions and normal tissue. However, this is made difficult by irregular margin borders …
lesions and normal tissue. However, this is made difficult by irregular margin borders …
DeepCleave: a deep learning predictor for caspase and matrix metalloprotease substrates and cleavage sites
Motivation Proteases are enzymes that cleave target substrate proteins by catalyzing the
hydrolysis of peptide bonds between specific amino acids. While the functional proteolysis …
hydrolysis of peptide bonds between specific amino acids. While the functional proteolysis …
Subtiligase-catalyzed peptide ligation
Subtiligase-catalyzed peptide ligation is a powerful approach for site-specific protein
bioconjugation, synthesis and semisynthesis of proteins and peptides, and chemoproteomic …
bioconjugation, synthesis and semisynthesis of proteins and peptides, and chemoproteomic …
Probing the correlation of neuronal loss, neurofibrillary tangles, and cell death markers across the Alzheimer's disease Braak stages: a quantitative study in humans
P Theofilas, AJ Ehrenberg, A Nguy, JM Thackrey… - Neurobiology of …, 2018 - Elsevier
Clarifying the mechanisms connecting neurofibrillary tangle (NFT) neurotoxicity to neuronal
dysfunction in humans is likely to be pivotal for developing effective treatments for …
dysfunction in humans is likely to be pivotal for developing effective treatments for …