Major reactive oxygen species (ROS)–producing systems in vascular wall include NADPH
(reduced form of nicotinamide adenine dinucleotide phosphate) oxidase, xanthine oxidase …

Coronary artery disease is the leading global cause of mortality. Long recognized to be
heritable, recent advances have started to unravel the genetic architecture of the disease …

532 Circulation Research February 19, 2016 unresolved questions and to exploit the newer
discoveries that have opened unanticipated horizons of understanding and raised novel …

Most of the biological understanding of mechanisms underlying coronary artery disease
(CAD) derives from studies of mouse models. The identification of multiple CAD loci and …

Atherosclerotic cardiovascular disease (ASCVD) is epidemic throughout the world and is
etiologic for such acute cardiovascular events as myocardial infarction, ischemic stroke …

Atherosclerosis is a vascular pathology characterized by inflammation and plaque build-up
within arterial vessel walls. Vessel occlusion, often occurring after plaque rupture, can result …

Genome-wide association studies (GWAS) have proven a fundamental tool to identify
common variants associated to complex traits, thus contributing to unveil the genetic …

Aims We tested the hypothesis that higher levels of plasma triglycerides and remnant
cholesterol are observationally and genetically associated with increased risk of aortic valve …

Polygenic scores quantify inherited risk by integrating information from many common sites
of DNA variation into a single number. Rapid increases in the scale of genetic association …

An exciting new era has dawned for the prevention and management of coronary artery
disease (CAD) utilizing genetic risk variants. The recent identification of over 60 …