The pentose phosphate pathway (PPP) is a glucose-oxidizing pathway that runs in parallel
to upper glycolysis to produce ribose 5-phosphate and nicotinamide adenine dinucleotide …

Neutrophil extracellular traps (NETs) evolved to protect the host against microbial infections
and are formed by a web-like structure of DNA that is decorated with antimicrobial effectors …

Neutrophils are cells at the frontline of innate immunity that can quickly activate effector
functions to eliminate pathogens upon stimulation. However, little is known about the …

Neutrophils are critical in the host defense against Staphylococcus aureus, a major human
pathogen. However, even in the setting of a robust neutrophil response, S. aureus can …

The gasdermins are a family of pore-forming proteins that have recently emerged as
executors of pyroptosis, a lytic form of cell death that is induced by the innate immune …

Macrophages infected with Gram-negative bacteria expressing Type III secretion system
(T3SS) activate the NLRC4 inflammasome, resulting in Gasdermin D (GSDMD)-dependent …

Neutrophils rely predominantly on glycolytic metabolism for their biological functions,
including reactive oxygen species (ROS) production. Although pyruvate kinase M2 (PKM2) …

Neutrophil extracellular traps (NETs) are DNA scaffolds coated with granule proteins that are
released by neutrophils to ensnare and kill bacteria. NET formation occurs in response to …

The liver can succumb to oxidant damage during the development of chronic liver diseases.
Despite their physiological relevance to hepatic homeostasis, excessive reactive …

Neutrophils are the most prevalent immune cells in circulation, but the repertoire of
canonical inflammasomes in neutrophils and their respective involvement in neutrophil IL …