Brain function critically depends on a close matching between metabolic demands,
appropriate delivery of oxygen and nutrients, and removal of cellular waste. This matching …

Pericytes are known as the mural cells in small-caliber vessels that interact closely with the
endothelium. Pericytes play a key role in vasculature formation and homeostasis, and when …

Cerebrovascular diseases are a leading cause of death and neurologic disability. Further
understanding of disease mechanisms and therapeutic strategies requires a deeper …

The vast majority of the brain's vascular length is composed of capillaries, where our
understanding of blood flow control remains incomplete. This review synthesizes current …

Intracerebral haemorrhage (ICH) is the second most common type of stroke and a major
cause of mortality and disability worldwide. Despite advances in surgical interventions and …

Capillaries are equipped to sense neurovascular coupling agents released onto the outer
wall of a capillary, translating these external signals into electrical/Ca2+ changes that play a …

Pericytes, attached to the surface of capillaries, play an important role in regulating local
blood flow. Using optogenetic tools and genetically encoded reporters in conjunction with …

The dense network of capillaries composed of capillary endothelial cells (cECs) and
pericytes lies in close proximity to all neurons, ideally positioning it to sense neuron-and …

Healthy brain function depends on the finely tuned spatial and temporal delivery of blood-
borne nutrients to active neurons via the vast, dense capillary network. Here, using in vivo …

Neurovascular coupling (NVC), which mediates rapid increases in cerebral blood flow in
response to neuronal activation, is commonly used to map brain activation or dysfunction …