The quest for ultrahigh detection sensitivity with spectroscopic contrasts other than
fluorescence has led to various novel approaches to optical microscopy of biological …

Imaging mass spectrometry has become a mature molecular mapping technology that is
used for molecular discovery in many medical and biological systems. While powerful by …

Advancements in coherent Raman scattering (CRS) microscopy have enabled label-free
visualization and analysis of functional, endogenous biomolecules in living systems. When …

Spectroscopic imaging has been an increasingly critical approach for unveiling specific
molecules in biological environments. Toward this goal, we demonstrate hyperspectral …

Real-time vibrational spectroscopic imaging is desired for monitoring cellular states and
cellular processes in a label-free manner. Raman spectroscopic imaging of highly dynamic …

Imaging techniques greatly facilitate the comprehensive knowledge of biological systems.
Although imaging methodology for biomacromolecules such as protein and nucleic acids …

The nematode Caenorhabditis elegans has been employed as a model organism to study
human obesity due to the conservation of the pathways that regulate energy metabolism. To …

The past decade has seen an enormous increase in the number and breadth of imaging
techniques developed for analysis in many industries, including pharmaceuticals, food, and …

Cellular biomolecules contain unique molecular vibrations that can be visualized by
coherent anti-Stokes Raman scattering (CARS) microscopy without the need for labels. Here …

Conspectus Traditionally, molecules are analyzed in a test tube. Taking biochemistry as an
example, the majority of our knowledge about cellular content comes from analysis of fixed …