Cells are exquisitely compartmentalized to achieve precise spatiotemporal regulation of
myriad processes and pathways. Phase separation offers one way to achieve territorial …

Ribonucleoprotein (RNP) granules are diverse membrane-less organelles that form through
multivalent RNA-RNA, RNA-protein, and protein-protein interactions between RNPs. RNP …

Full-grown oocytes are transcriptionally silent and must stably maintain the messenger
RNAs (mRNAs) needed for oocyte meiotic maturation and early embryonic development …

RNA-binding proteins (RBPs) regulate essentially every event in the lifetime of an RNA
molecule, from its production to its destruction. Whereas much has been learned about RNA …

RNA granules are mesoscale assemblies that form in the absence of limiting membranes.
RNA granules contain factors for RNA biogenesis and turnover and are often assumed to …

As our understanding of the cell interior has grown, we have come to appreciate that most
cellular operations are localized, that is, they occur at discrete and identifiable locations or …

The maturation of liquid-like protein condensates into amyloid fibrils has been associated
with several neurodegenerative diseases. However, the molecular mechanisms underlying …

The importance of subcellular mRNA localization is well established, but the underlying
mechanisms mostly remain an enigma. Early studies suggested that specific mRNA …

Plant nucleotide-binding leucine-rich repeat (NLR) immune receptors with an N-terminal
Toll/interleukin-1 receptor (TIR) domain mediate recognition of strain-specific pathogen …

Germ granules, condensates of phase-separated RNA and protein, are organelles that are
essential for germline development in different organisms. The patterning of the granules …