With their power to shape animal morphology, few genes have captured the imagination of
biologists as the evolutionarily conserved members of the Hox clusters have done. Recent …

Hox proteins are well known for executing highly specific functions in vivo, but our
understanding of the molecular mechanisms underlying gene regulation by these …

Homeotic (Hox) genes code for principal transcriptional regulators of animal body
regionalization. The duplication and divergence of Hox genes, changes in their regulation …

Control rules governing transciption of eukaryotic genes can be modeled as Boolean
function, and these rules are strongly biased toward large numbers of “canalizing” inputs …

Pbx cofactors are implicated to play important roles in modulating the DNA-binding
properties of heterologous homeodomain proteins, including class I Hox proteins. To assess …

Transcription factors (TFs) control gene expression by binding to genomic DNA in a
sequence-specific manner. Mutations in TF binding sites are increasingly found to be …

Hox genes encode conserved transcription factors expressed along the antero-posterior
axis of vertebrates and invertebrates. In both phyla, HOX proteins control the formation of …

Homeotic (Hox) genes regulate the identity of structures along the anterior-posterior axis of
most animals. The low DNA-binding specificities of Hox proteins have raised the question of …

Selector proteins regulate the formation and identity of animal body regions, organs, tissues,
and cell types. Recent studies have focused on the regulation of the DNA binding and …

The homeotic genes of the bithorax complex are required, among other things, for
establishing the patterns of sensory organs in the embryonic peripheral nervous system …