Interpreting the language of histone and DNA modifications
SB Rothbart, BD Strahl - Biochimica et Biophysica Acta (BBA)-Gene …, 2014 - Elsevier
A major mechanism regulating the accessibility and function of eukaryotic genomes are the
covalent modifications to DNA and histone proteins that dependably package our genetic …
covalent modifications to DNA and histone proteins that dependably package our genetic …
Epigenetic mechanisms in neurogenesis
In the embryonic and adult brain, neural stem cells proliferate and give rise to neurons and
glia through highly regulated processes. Epigenetic mechanisms—including DNA and …
glia through highly regulated processes. Epigenetic mechanisms—including DNA and …
Dynamic readers for 5-(hydroxy) methylcytosine and its oxidized derivatives
CG Spruijt, F Gnerlich, AH Smits, T Pfaffeneder… - Cell, 2013 - cell.com
Tet proteins oxidize 5-methylcytosine (mC) to generate 5-hydroxymethyl (hmC), 5-formyl
(fC), and 5-carboxylcytosine (caC). The exact function of these oxidative cytosine bases …
(fC), and 5-carboxylcytosine (caC). The exact function of these oxidative cytosine bases …
[HTML][HTML] Understanding the relationship between DNA methylation and histone lysine methylation
DNA methylation acts as an epigenetic modification in vertebrate DNA. Recently it has
become clear that the DNA and histone lysine methylation systems are highly interrelated …
become clear that the DNA and histone lysine methylation systems are highly interrelated …
[HTML][HTML] DNA methylation, its mediators and genome integrity
H Meng, Y Cao, J Qin, X Song, Q Zhang… - … journal of biological …, 2015 - ncbi.nlm.nih.gov
DNA methylation regulates many cellular processes, including embryonic development,
transcription, chromatin structure, X-chromosome inactivation, genomic imprinting and …
transcription, chromatin structure, X-chromosome inactivation, genomic imprinting and …
Tet oxidizes thymine to 5-hydroxymethyluracil in mouse embryonic stem cell DNA
T Pfaffeneder, F Spada, M Wagner… - Nature chemical …, 2014 - nature.com
Ten eleven translocation (Tet) enzymes oxidize the epigenetically important DNA base 5-
methylcytosine (mC) stepwise to 5-hydroxymethylcytosine (hmC), 5-formylcytosine and 5 …
methylcytosine (mC) stepwise to 5-hydroxymethylcytosine (hmC), 5-formylcytosine and 5 …
DNA methylation requires a DNMT1 ubiquitin interacting motif (UIM) and histone ubiquitination
W Qin, P Wolf, N Liu, S Link, M Smets, FL Mastra… - Cell research, 2015 - nature.com
DNMT1 is recruited by PCNA and UHRF1 to maintain DNA methylation after replication.
UHRF1 recognizes hemimethylated DNA substrates via the SRA domain, but also …
UHRF1 recognizes hemimethylated DNA substrates via the SRA domain, but also …
Coordinated dialogue between UHRF1 and DNMT1 to ensure faithful inheritance of methylated DNA patterns
DNA methylation, catalyzed by DNA methyltransferases (DNMTs), is an epigenetic mark that
needs to be faithfully replicated during mitosis in order to maintain cell phenotype during …
needs to be faithfully replicated during mitosis in order to maintain cell phenotype during …
Parallel mechanisms of epigenetic reprogramming in the germline
JA Hackett, JJ Zylicz, MA Surani - Trends in Genetics, 2012 - cell.com
Germ cells possess the extraordinary and unique capacity to give rise to a new organism
and create an enduring link between all generations. To acquire this property, primordial …
and create an enduring link between all generations. To acquire this property, primordial …
Hemi-methylated DNA opens a closed conformation of UHRF1 to facilitate its histone recognition
UHRF1 is an important epigenetic regulator for maintenance DNA methylation. UHRF1
recognizes hemi-methylated DNA (hm-DNA) and trimethylation of histone H3K9 (H3K9me3) …
recognizes hemi-methylated DNA (hm-DNA) and trimethylation of histone H3K9 (H3K9me3) …