Widespread antisense transcription in prokaryotes

J Georg, WR Hess - Microbiology Spectrum, 2018 - Am Soc Microbiol
Although bacterial genomes are usually densely protein-coding, genome-wide mapping
approaches of transcriptional start sites revealed that a significant fraction of the identified …

Recent insights into the world of dual‐function bacterial sRNAs

SB Schnoor, P Neubauer… - Wiley Interdisciplinary …, 2024 - Wiley Online Library
Dual‐function sRNAs refer to a small subgroup of small regulatory RNAs that merges base‐
pairing properties of antisense RNAs with peptide‐encoding properties of mRNA. Both …

Engineering Corynebacterium glutamicum for high-titer biosynthesis of hyaluronic acid

F Cheng, H Yu, G Stephanopoulos - Metabolic engineering, 2019 - Elsevier
Hyaluronic acid (HA) is a member of the glycosaminoglycan family and has been widely
used in the clinical, medical, cosmetic and food industries. In this study, we constructed a …

Metabolic engineering of Bacillus subtilis fueled by systems biology: recent advances and future directions

Y Liu, J Li, G Du, J Chen, L Liu - Biotechnology advances, 2017 - Elsevier
By combining advanced omics technology and computational modeling, systems biologists
have identified and inferred thousands of regulatory events and system-wide interactions of …

Small proteins in Gram-positive bacteria

S Brantl, I Ul Haq - FEMS Microbiology Reviews, 2023 - academic.oup.com
Small proteins comprising less than 100 amino acids have been often ignored in bacterial
genome annotations. About 10 years ago, focused efforts started to investigate whole …

Cis- and Trans-Encoded Small Regulatory RNAs in Bacillus subtilis

S Brantl, P Müller - Microorganisms, 2021 - mdpi.com
Small regulatory RNAs (sRNAs) that act by base-pairing are the most abundant
posttranscriptional regulators in all three kingdoms of life. Over the past 20 years, a variety of …

Regulatory RNAs in Bacillus subtilis: a Gram-positive perspective on bacterial RNA-mediated regulation of gene expression

RAT Mars, P Nicolas, EL Denham… - … and Molecular Biology …, 2016 - Am Soc Microbiol
Bacteria can employ widely diverse RNA molecules to regulate their gene expression. Such
molecules include trans-acting small regulatory RNAs, antisense RNAs, and a variety of …

Antisense RNA-Based Strategy for Enhancing Surfactin Production in Bacillus subtilis TS1726 via Overexpression of the Unconventional Biotin Carboxylase II To …

M Wang, H Yu, Z Shen - ACS Synthetic Biology, 2019 - ACS Publications
The antisense RNA (asRNA) strategy is commonly used to block protein expression and
downregulate the contents of metabolites in several microorganisms. Here, we show that the …

Riboregulation in bacteria: From general principles to novel mechanisms of the trp attenuator and its sRNA and peptide products

E Evguenieva‐Hackenberg - Wiley Interdisciplinary Reviews …, 2022 - Wiley Online Library
Gene expression strategies ensuring bacterial survival and competitiveness rely on cis‐and
trans‐acting RNA‐regulators (riboregulators). Among the cis‐acting riboregulators are …

Management of Osmoprotectant Uptake Hierarchy in Bacillus subtilis via a SigB-Dependent Antisense RNA

H Rath, A Reder, T Hoffmann, E Hammer… - Frontiers in …, 2020 - frontiersin.org
Under hyperosmotic conditions, bacteria accumulate compatible solutes through synthesis
or import. Bacillus subtilis imports a large set of osmostress protectants via five osmotically …