The struggle to end a millennia-long pandemic: novel candidate and repurposed drugs for the treatment of tuberculosis

BD Edwards, SK Field - Drugs, 2022 - Springer
This article provides an encompassing review of the current pipeline of putative and
developed treatments for tuberculosis, including multidrug-resistant strains. The review has …

Development of new tuberculosis drugs: translation to regimen composition for drug-sensitive and multidrug-resistant tuberculosis

JP Ernest, N Strydom, Q Wang, N Zhang… - Annual review of …, 2021 - annualreviews.org
Tuberculosis (TB) kills more people than any other infectious disease. Challenges for
developing better treatments include the complex pathology due to within-host immune …

Tricyclic SpiroLactams kill mycobacteria in vitro and in vivo by inhibiting type II NADH dehydrogenases

S Dam, S Tangara, C Hamela, T Hattabi… - Journal of Medicinal …, 2022 - ACS Publications
It is critical that novel classes of antituberculosis drugs are developed to combat the
increasing burden of infections by multidrug-resistant strains. To identify such a novel class …

Phage Cocktails Constrain the Growth of Enterococcus

S Wandro, P Ghatbale, H Attai, C Hendrickson… - Msystems, 2022 - Am Soc Microbiol
Phages that infect pathogenic bacteria present a valuable resource for treating antibiotic-
resistant infections. We isolated and developed a collection of 19 Enterococcus phages …

One Size Fits All? Not in In Vivo Modeling of Tuberculosis Chemotherapeutics

HJ Yang, D Wang, X Wen, DM Weiner… - Frontiers in Cellular and …, 2021 - frontiersin.org
Tuberculosis (TB) remains a global health problem despite almost universal efforts to
provide patients with highly effective chemotherapy, in part, because many infected …

Lactate metabolism and signaling in tuberculosis and cancer: a comparative review

D Kiran, RJ Basaraba - Frontiers in Cellular and Infection …, 2021 - frontiersin.org
Infection with Mycobacterium tuberculosis (Mtb) leading to tuberculosis (TB) disease
continues to be a major global health challenge. Critical barriers, including but not limited to …

The lung microbiome, vitamin D, and the tuberculous granuloma: A balance triangle

ME Balcells, N Yokobori, B Hong, J Corbett… - Microbial …, 2019 - Elsevier
Mycobacterium tuberculosis (Mtb) has the extraordinary ability to persist for decades within
granulomas in the human host. These histopathological structures involved in both …

Burden of tuberculosis and its association with socio-economic development status in 204 countries and territories, 1990–2019

Y Xue, J Zhou, P Wang, J Lan, W Lian, YY Fan… - Frontiers in …, 2022 - frontiersin.org
Background Tuberculosis (TB) always runs in the forefront of the global burden when it
comes to infectious diseases. Tuberculosis, which can lead to impairment of quality of life …

Advances in the application of 1, 2, 4-triazole-containing hybrids as anti-tuberculosis agents

Y Cao, H Lu - Future Medicinal Chemistry, 2021 - Taylor & Francis
Tuberculosis is a deadly communicable disease caused by the bacillus Mycobacterium
tuberculosis (MTB), and pulmonary tuberculosis accounts for over 80% of the total cases …

Vulnerability and tuberculosis treatment outcomes in urban settings in England: A mixed-methods study

LC Berrocal-Almanza, M Lima, H Piotrowski… - Plos one, 2023 - journals.plos.org
Background Evidence on factors contributing to poor treatment outcome and healthcare
priorities in vulnerable populations affected by tuberculosis (TB) in urban areas of England …