Positron emission tomography (PET) is an imaging technology that can detect and
characterize tumors based on their molecular and biochemical properties, such as altered …

Immunotherapy with checkpoint inhibitors demonstrates impressive improvements in the
treatment of several types of cancer. Unfortunately, not all patients respond to therapy while …

Immunotherapy based on host immunity has emerged as a powerful therapeutic strategy for
tumor treatment. However, utilizing the immune system against tumors often fails to result in …

Aim Despite current treatments, high-grade meningiomas continue to have a poor
prognosis. Immunotherapy targeting immune checkpoints, such as PD-L1, has …

Introduction There is mounting evidence supporting the role of tryptophan metabolism via
the kynurenine pathway (KP) in the pathogenesis of primary brain tumors. Under normal …

Due to its metabolism via the serotonin and kynurenine pathways, tryptophan plays a key
role in multiple disease processes including cancer. Imaging tryptophan uptake and …

Anhedonia, characterized by a loss of interest and/or pleasure in previously enjoyable
activities, is an important diagnostic criterion of Major Depressive Disorder (MDD) …

Background Increased tryptophan metabolism via the kynurenine pathway (KP) is a key
mechanism of tumoral immune suppression in gliomas. However, details of tryptophan …

Primary brain tumors, both malignant and benign, are diagnosed in adults at an incidence
rate of approximately 23 people per 100 thousand. The role of AhR in carcinogenesis has …

Purpose The aim of this study was to assess whether dynamic PET with 11 C-methionine
(MET)(MET-PET) is useful in the diagnosis of brain tumors. Methods One hundred sixty …