Type 3 diabetes and its role implications in Alzheimer's disease

TT Nguyen, QTH Ta, TKO Nguyen… - International journal of …, 2020 - mdpi.com
The exact connection between Alzheimer's disease (AD) and type 2 diabetes is still in
debate. However, poorly controlled blood sugar may increase the risk of developing …

The roles of dietary polyphenols at crosstalk between type 2 diabetes and Alzheimer's disease in ameliorating oxidative stress and mitochondrial dysfunction via PI3K …

J Wang, J Zhang, ZL Yu, SK Chung, B Xu - Ageing Research Reviews, 2024 - Elsevier
Alzheimer's disease (AD) is a fatal neurodegenerative disease in which senile plaques and
neurofibrillary tangles are crucially involved in its physiological and pathophysiological …

Role of the metabolism of branched-chain amino acids in the development of Alzheimer's disease and other metabolic disorders

B Polis, AO Samson - Neural regeneration research, 2020 - journals.lww.com
Alzheimer's disease is an incurable chronic neurodegenerative disorder and the leading
cause of dementia, imposing a growing economic burden upon society. The disease …

Cognitive dysfunction: a growing link between diabetes and Alzheimer's disease

K Jash, P Gondaliya, P Kirave… - Drug development …, 2020 - Wiley Online Library
Diabetes mellitus (DM) is a gradually rising metabolic disease which is currently affecting
millions of people worldwide. Diabetes is associated with various complications like …

Physical exercise, IGF-1 and cognition A systematic review of experimental studies in the elderly

AM Stein, TMV Silva, FGM Coelho… - Dementia & …, 2018 - SciELO Brasil
One of hypothetical mechanisms related to cognition is exercise-induced IGF-1. Objective:
The aim of this study was to analyze the effects of exercise on IGF-1 levels and cognition in …

Linagliptin, a dipeptidyl peptidase-4 inhibitor, mitigates cognitive deficits and pathology in the 3xTg-AD mouse model of Alzheimer's disease

J Kosaraju, RMD Holsinger, L Guo, KY Tam - Molecular Neurobiology, 2017 - Springer
Abstract Glucagon-like peptide-1 (GLP-1) is an incretin hormone shown to be active in the
treatment of type-2 diabetes (T2D) and has also been shown as efficacious in Alzheimer's …

The chemical profiling and assessment of antioxidative, antidiabetic and antineurodegenerative potential of Kombucha fermented Camellia sinensis, Coffea arabica …

MO Pavlović, M Stajić, U Gašić, S Duletić-Laušević… - Food & function, 2023 - pubs.rsc.org
The scientific interest in the medicinal properties of Kombucha beverages, a carbonated
drink with live microorganisms, has increased recently. Hence, the aim of this study was to …

Role of sex and high-fat diet in metabolic and hypothalamic disturbances in the 3xTg-AD mouse model of Alzheimer's disease

LS Robison, OJ Gannon, MA Thomas… - Journal of …, 2020 - Springer
Background Hypothalamic dysfunction occurs early in the clinical course of Alzheimer's
disease (AD), likely contributing to disturbances in feeding behavior and metabolic function …

Human serum albumin in neurodegeneration

S Shojai, SA Haeri Rohani… - Reviews in the …, 2022 - degruyter.com
Serum albumin (SA) exists in relatively high concentrations, in close contact with most cells.
However, in the adult brain, except for cerebrospinal fluid (CSF), SA concentration is …

[HTML][HTML] HMGB1 signaling pathway in diabetes-related dementia: Blood-brain barrier breakdown, brain insulin resistance, and Aβ accumulation

J Jeong, DH Lee, J Song - Biomedicine & Pharmacotherapy, 2022 - Elsevier
Diabetes contributes to the onset of various diseases, including cancer and cardiovascular
and neurodegenerative diseases. Recent studies have highlighted the similarities and …