Microbial translocation in the pathogenesis of HIV infection and AIDS

G Marchetti, C Tincati, G Silvestri - Clinical microbiology reviews, 2013 - Am Soc Microbiol
In pathogenic simian immunodeficiency virus (SIV) and human immunodeficiency virus
(HIV) infections, the translocation of microbial products from the gastrointestinal (GI) tract to …

Oncogenic effects of HIV-1 proteins, mechanisms behind

M Isaguliants, E Bayurova, D Avdoshina… - Cancers, 2021 - mdpi.com
Simple Summary People living with human immunodeficiency virus type 1 (HIV-1)(PLWH)
are at increased risk of developing cancer despite successful antiretroviral therapy (ART) …

Microbial translocation is associated with sustained failure in CD4+ T-cell reconstitution in HIV-infected patients on long-term highly active antiretroviral therapy

G Marchetti, GM Bellistrì, E Borghi, C Tincati… - Aids, 2008 - journals.lww.com
Patients with inefficient CD4+ T-cell recovery on virogically suppressive highly active
antiretroviral therapy constitute a major clinical hurdle given the threat of HIV/AIDS disease …

The effects of circumcision on the penis microbiome

LB Price, CM Liu, KE Johnson, M Aziz, MK Lau… - PloS one, 2010 - journals.plos.org
Background Circumcision is associated with significant reductions in HIV, HSV-2 and HPV
infections among men and significant reductions in bacterial vaginosis among their female …

The Absence of CD4+ T Cell Count Recovery Despite Receipt of Virologically Suppressive Highly Active Antiretroviral Therapy: Clinical Risk, Immunological Gaps …

L Gazzola, C Tincati, GM Bellistré… - Clinical Infectious …, 2009 - academic.oup.com
Up to 30% of human immunodeficiency virus (HIV)–infected patients who are receiving long-
term highly active antiretroviral therapy do not exhibit a marked increase in the CD4+ T cell …

Immunology of pediatric HIV infection

NH Tobin, GM Aldrovandi - Immunological reviews, 2013 - Wiley Online Library
Most infants born to human immunodeficiency virus (HIV)‐infected women escape HIV
infection. Infants evade infection despite an immature immune system and, in the case of …

Susceptibility of human Th17 cells to human immunodeficiency virus and their perturbation during infection

A El Hed, A Khaitan, L Kozhaya, N Manel… - The Journal of …, 2010 - academic.oup.com
Abstract Background. Identification of the Th17 T cell subset as important mediators of host
defense and pathology prompted us to determine their susceptibility to human immuno …

Systemic administration of combinatorial dsiRNAs via nanoparticles efficiently suppresses HIV-1 infection in humanized mice

J Zhou, CP Neff, X Liu, J Zhang, H Li, DD Smith… - Molecular Therapy, 2011 - cell.com
We evaluated the in vivo efficacy of structurally flexible, cationic PAMAM dendrimers as a
small interfering RNA (siRNA) delivery system in a Rag2‐/‐γc‐/‐(RAG-hu) humanized …

Gut Lactobacillales are associated with higher CD4 and less microbial translocation during HIV infection

J Pérez-Santiago, S Gianella, M Massanella, CA Spina… - Aids, 2013 - journals.lww.com
Objective: Early HIV infection is characterized by a dramatic depletion of CD4 T cells in the
gastrointestinal tract and translocation of bacterial products from the gut into the blood. In …

Disruption of intestinal CD4+ T cell homeostasis is a key marker of systemic CD4+ T cell activation in HIV-infected individuals

SN Gordon, B Cervasi, P Odorizzi… - The Journal of …, 2010 - journals.aai.org
HIV infection is associated with depletion of intestinal CD4+ T cells, resulting in mucosal
immune dysfunction, microbial translocation, chronic immune activation, and progressive …