Fibrinolysis is a series of enzymatic reactions that degrade insoluble fibrin. Plasminogen
activators convert the zymogen plasminogen to the active serine protease plasmin, which …

Fibrinolysis is an important process in hemostasis responsible for dissolving the clot during
wound healing. Plasmin is a central enzyme in this process via its capacity to cleave fibrin …

Antifibrinolytic drugs are used extensively for on-demand treatment of severe acute
bleeding. Controlling fibrinolysis may also be an effective strategy to prevent or lessen …

Background The optimal dose of tranexamic acid to inhibit hyperfibrinolysis in postpartum
haemorrhage is unclear. Tranexamic Acid to Reduce Blood Loss in Hemorrhagic Cesarean …

Background Tranexamic acid is an antifibrinolytic drug that is commonly administered for
obstetric haemorrhage. Conventional viscoelastic tests are not sensitive to tranexamic acid …

Abstract Background C1-inhibitor (C1INH) is a broad-acting serine protease inhibitor with
anticoagulant activity. The impact of C1INH plasma levels within the normal physiological …

Abstract The American Trial Using Tranexamic Acid (TXA) in Thrombocytopenia (A-TREAT,
NCT02578901) demonstrated no superiority of TXA over placebo in preventing World …

In the last decades, tranexamic acid (TXA) has emerged as an essential tool in blood loss
management in obstetrics. TXA prophylaxis for postpartum haemorrhage (PPH) has been …

Ex vivo viscoelastic testing can be used to assess the concentration responses to
tranexamic acid in blood samples obtained from pregnant women across the three …

Aims The population pharmacokinetics (PK) and pharmacodynamics (PD) of tranexamic
acid (TXA) have not been studied to prevent postpartum haemorrhage (PPH) in pregnant …