The veterinary immunological toolbox: past, present, and future

G Entrican, JK Lunney, SR Wattegedera… - Frontiers in …, 2020 - frontiersin.org
It is well-recognized that research capability in veterinary species is restricted by a lack of
immunological reagents relative to the extensive toolboxes for small rodent biomedical …

Intestinal single-cell atlas reveals novel lymphocytes in pigs with similarities to human cells

JE Wiarda, JM Trachsel… - Life science …, 2022 - life-science-alliance.org
Lymphocytes can heavily influence intestinal health, but resolving intestinal lymphocyte
function is challenging as the intestine contains a vastly heterogeneous mixture of cells. Pigs …

Swine models for translational oncological research: an evolving landscape and regulatory considerations

AN Boettcher, KM Schachtschneider, LB Schook… - Mammalian …, 2022 - Springer
Swine biomedical models have been gaining in popularity over the last decade, particularly
for applications in oncology research. Swine models for cancer research include pigs that …

Pigs as Clinically Relevant Models for Synergizing Interventional Oncology and Immunotherapy

J Lee, FE Boas, R Duran-Struuck, RC Gaba… - Journal of Vascular and …, 2024 - Elsevier
Traditionally, rodent cancer models have driven preclinical oncology research. However,
they do not fully recapitulate characteristics of human cancers, and their size poses …

Allogeneic and xenogeneic lymphoid reconstitution in a RAG2−/−IL2RGy/− severe combined immunodeficient pig: A preclinical model for intrauterine …

RB Sper, J Proctor, O Lascina, L Guo… - Frontiers in Veterinary …, 2022 - frontiersin.org
Mice with severe combined immunodeficiency are commonly used as hosts of human cells.
Size, longevity, and physiology, however, limit the extent to which immunodeficient mice can …

Porcine intestinal innate lymphoid cells and lymphocyte spatial context revealed through single-cell RNA sequencing

JE Wiarda, JM Trachsel, SK Sivasankaran, CK Tuggle… - bioRxiv, 2022 - biorxiv.org
Intestinal lymphocytes are crucial members of the mucosal immune system with impact over
outcomes of intestinal health versus dysbiosis. Resolving intestinal lymphocyte complexity …