Immunotherapy is known to be clinically beneficial for cancer patients and in many cases
represents the new standard of care. Because of this success, the interest in integrating …

The evolutionary theory of aging has set the foundations for a comprehensive understanding
of aging. The biology of aging has listed and described the “hallmarks of aging,” ie, cellular …

Paeoniflorin is one of the important components in Paeoniaceae plants. In this study, we
used Caenorhabditis elegans as a model host and Pseudomonas aeruginosa as a bacterial …

Neuroendocrine control mechanisms are observed in all animals that possess a nervous
system. Recent analyses of neuroendocrine functions in invertebrate model systems reveal …

Cells have evolved complex mechanisms to maintain protein homeostasis, such as the UPR
ER, which are strongly associated with several diseases and the aging process. We …

A conserved insulin-like pathway modulates both aging and pathogen resistance in
Caenorhabditis elegans. However, the specific innate effector functions that mediate this …

In the clinical intensive care units (ICU), the traditional Chinese medicine (TCM) formulation
of Xuebijing has been frequently used for treating sepsis. Nevertheless, the underlying …

While Caenorhabditis elegans specifically responds to infection by the up-regulation of
certain genes, distinct pathogens trigger the expression of a common set of genes. We …

Six lactic acid bacterial (LAB) strains were isolated from traditionally fermented Xinjiang
cheese and evaluated for functional and probiotic properties and potentials as starter …

The interaction between the nematode Caenorhabditis elegans and a Gram-positive
bacterial pathogen, Microbacterium nematophilum, provides a model for an innate immune …